摘要
目的研究血清胱抑素-C（serum cystatin C，sCysC）与尿白细胞介素-18（urinary interleukin 18，uIL-18）的变化对ICU重症患者发生急性肾损伤（AKI）早期预测作用。方法根据纳入标准选择我院ICU收治的危重症患者为研究对象，每天收集血、尿标本，持续1周。ELISA法检测尿液标本中uIL-18含量，免疫比浊法测量sCys C含量。根据测量结果分为4组：A组（uIL-18〉100pg／mL）、B组（sCys C〉1．5mg／L）、C组（uIL-18〉100pg／mL和sCys C〉1．5mg／L）和D组（IL-18≤100ps／mL和sCys C≤1．5mg／L），观察各组AKI发病率。结果一周内AKI的发病率A、B、C3组与D组比较差异有统计学意义。用ROC曲线来分析sCys C和uIL-18对AKI的预测作用，sCys C、uIL-18、sCysC联合uIL-18的曲线下面积分别为0．587（P〉0．05）、0．793（P〈0．05）、0．850（P〈0．05）。结论sCys C、uIL-18及sCys C联合uIL-18对ICU中AKI均有早期诊断作用，二者联合诊断AKI优于单一指标。
Objective To study the role of serum cystatin C （ sCys C） combined with urinary interleukin - 18（ ulL - 18） in early diagnosis of acute kidney injury（AKI） of critically ill patients in ICU. Methods According to the inclusion criteria, critically ill patients in our hospital admitted to ICU were selected for the study, and blood and urine samples were collected daily for 1 week. Urine specimens were analyzed by enzyme - linked immunosorbent assay for uIL - 18, and particle reinforced nephelometric y for the sCys C concentration. According to measurement results, the patients were divided into three groups： group A （uIL - 18 〉 100 pg/mL）, group B （ sCys C 〉 1.5 mg/L）, group C（uIL - 18 〉 100 pg/mL and sCys C 〉 1.5 mg/L）, group D（IL - 18≤100 pg/mL and sCys C≤ 1.5 mg/L）. The incidence of AKI was observed in each group. Results The incidence of AKI within a week were significantly different between group A, B, C and group D. ROC curve was used to analyze the prediction of sCys C and uIL - 18 in AKI, the area under the curve of sCys C, uIL - 18, sCys C and ulL-18were0.587（P〉0. 05）, 0.793（P〈0.05）, 0.850（P〈0.05）. Conclusion Both sCys C and uIL- 18 play an important roles in early diagnosis of AKI, and their combination is superior to single.
出处
《中国急救医学》
CAS
CSCD
北大核心
2012年第9期800-803,共4页
Chinese Journal of Critical Care Medicine
基金
基金项目：兰州军区卫生资助项目（XLH2009027）
