摘要
目的恶性胸腔积液是晚期恶性肿瘤的并发症,一旦出现患者生活质量将受到很大影响。本研究旨在观察康莱特联合顺铂治疗恶性胸腔积液患者的临床疗效和毒副反应。方法本组42例恶性胸腔积液,随机分成两组:两组每次胸腔注药前均胸腔内注入生理盐水加地塞米松5 mg,单药顺铂组顺铂60 mg加生理盐水30 mL胸腔内注射,联用组康莱特200 mL注入胸腔夹管48 h放开引流,尽量流尽液体后胸腔注入顺铂60 mg加生理盐水30 mL。结果单药组CR+PR是57.14%,联合组CR+PR是90.48%,两组疗效经X2检验有显著性差异P<0.05。结论康莱特与顺铂联用,治疗恶性胸腔积液副作用小、疗效高。
Objective To observe the therapeutic effect and the toxic - adverse reaction of kanglaite combined with eis-platin in the treatment for malignant pleural effusion, which is a malignant tumor of late stage complication. Methods 42 cases were randomly divided into two groups-the single group and combined group. Before we experiment, normal saline and dexamethasone with 5mg should be injected. Then the cisplatin with 60mg and normal saline with 30ml was injected into intrapleural cavity in sinle group. In the combined group , the Kanglaite with 200ml was injected first and opened drainage 48h later, as the liquid flowe, the the cisplatin 60mg and normal saline 30ml were injected. Results The effec- tive rate （ CR ＋ PR） was 57.14 % in the single group and 90.48 % in the combined group. There were significant differ-ences on effective rate which were tested with X2between two groups（ P 〈 0.05）. Conclusions kanglaite combined with cisplatin in the Treatment for Malignant pleural effusion has higher curative effect and smaller side-effect.
出处
《现代中医药》
CAS
2012年第5期39-40,共2页
Modern Chinese Medicine
关键词
恶性胸腔积液
康莱特
顺铂
Malignant pleural effusion
Kanglaite
Cisplatin
