摘要
目的:探讨促性腺激素释放激素激动剂联合反向添加法治疗子宫内膜异位症的可行性。方法:将子宫内膜异位症患者102例按照入院的先后顺序随机分为三组,其中50例行促性腺激素释放激素激动剂(GnRH-a)加反向添加法治疗(Ⅰ组),28例行GnRH-a退缩疗法(Ⅱ组),24例作为对照组(Ⅲ组),对比三组治疗的临床疗效、垂体-卵巢轴内分泌变化及副反应。结果:三组内相比,Ⅰ组和Ⅱ组的总有效率分别为96.0%和85.7%,明显高于Ⅲ组的75.0%(P<0.05)。Ⅰ组和Ⅱ组患者的血清E2、FSH、LH、P水平下降明显(P<0.05),且未造成骨密度改变(P>0.05)。结论:运用GnRH-a加反向添加法治疗子宫内膜异位症,临床效果明显优于退缩疗法和常规处理,并可使患者内分泌恢复正常,副作用较小。
Objectives： To explore the effect of gonadotropin releasing hormone agonist （GnRH agonist） combined with add - back therapy for the treatment of endometriosis. Methods： A total of 102 patients with endometriosis were randomly divided into three groups ： 50 patients treated with gonadotropin releasing hormone agonist （ GnRH - a ） combined with add - back therapy （ group Ⅰ）, 28 patients treated with GnRH - a withdrawal therapy （ group Ⅱ）, 24 patients included as the control group （ group Ⅲ ）. The three groups were compared in terms of curative efficacy, pituitary ovarian axis endocrine changes and side effects. Results： The total effective rates in Group Ⅰ and Ⅱwere respectively 96% and 85.7%, significantly higher than the rate of 75% in Group Ⅲ （P 〈0. 05）75%. Patients in group Ⅰand Ⅱ showed significantly decreased level of serum E2, FSH, LH, P （ P 〈 0. 05 ）, but litde changes in bone mineral density （ P 〉 0. 05 ）. Conclusion： The use of GnRH - a combined with add - back therapy have better effect than withdrawal therapy and conventional treatment for endometriosis. It can restore the normal endocrine function and produce little side effects.
出处
《中国性科学》
2012年第9期32-34,共3页
Chinese Journal of Human Sexuality
关键词
促性腺激素释放激素激动剂
反向添加法
子宫内膜异位症
Gonadotropin releasing hormone agonist（ GnRH agonist ）
Reverse adding method
Endometriosis
