摘要
目的探讨燃煤氟砷致暴露人群骨代谢损伤的生物暴露限值（BEL）。方法2009年选择贵州省清镇市流长乡198例氟砷联合暴露者作为调查对象。分别检测尿氟、尿砷及骨代谢效应标志尿羟脯氨酸（UHYP）和尿I型胶原交联氨基末端肽（UNTX）、骨强度指数（STI）。应用BMDSVersion2．1软件计算燃煤氟砷致骨代谢损伤的尿氟、尿砷基准剂量（BMD）及其可信限下限（BMDL）。结果氟、砷混合暴露引起骨代谢损伤的尿氟BMD及BMDL范围分别为0．68—1．35mg／g Cr和0．57～1．11mg／g Cr；尿砷BMD及BMDL范围分别为8．36～18．77μg／gCr和7．12－15．40Cs／gCr。结论建议燃煤氟砷混合暴露引起骨代谢损伤的生物暴露限值，尿氟为0．57mg／gCr，尿砷为7．12μg／gCr。
Objective To study the biological exposure limit in bone metabolism damage caused by coexposure to fluorine and arsenic from coal burning in exposed population. Methods One hundred and ninety-eight cases of fluoride and arsenic co-exposed people from Liuchang village, Qinzhen city, Guizhou province were enrolled in the study. Urinary fluorine （UF）, urinary arsenic （UAs）, urinary hydroxyproline （UHYP）, ross-linked N- telopeptides of type I collagen（UNTX） and bone strength index（STI） were detected. BMDS Version 2.1 software was used to calculate UF, UAs benchmark dose （BMD） and its lower confidence limit （BMDL） on the damage of bone metabolism caused by co-exposure to fluorine and arsenic from coal burning. Results The BMD and BMDL range of UF caused by co-exposure to fluorine and arsenic from coal burning were 0.68 - 1.35 mg/g Cr, 0.57 - 1.11 mg/g Cr. The BMD and BMDL range of UAs caused by co-exposure to fluorine and arsenic from coal burning were 8.36 - 18.77μg/g Cr,7.12 - 15.40μg/g Cr. Conclusion The biological exposure limits of UF and UAs for bone metabohsm toxicity are proposed as 0.57 mg/g Cr and 7.12 μg/g Cr in co-exposure to fluoride and arsenic from coal burning, respectively.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2012年第5期523-525,共3页
Chinese Jouranl of Endemiology
基金
国家自然科学基金（30660163、81072248）
贵州省优秀青年科技人才培养计划专项资金（黔科合人字[2007]12号）
贵州省科学技术基金（黔科通[2006]63号）
贵州省教育厅自然科学科研基金（黔教高发[2005]328号）
关键词
氟
砷
基准剂量
生物暴露限值
Fluoride
Arsenic
Benchmark dose
Biological exposure limit
