摘要
目的探讨二甲基甲酰胺职业暴露与作业人员慢性非萎缩性胃炎的相关性。方法对4家企业385名员工进行健康状况调查,将发现的28例慢性非萎缩性胃炎现患者设为病例组,所有对象经性别、年龄排序后,按性别一致、年龄±1岁分组,在每个病例对应的组中,统一依次按"隔位选一"原则选取4名无现患者(1∶4配对),共112名工人为对照组,开展病例对照研究。相关性分析与评价采用卡方检验和条件Logistic回归分析。结果 (1)慢性非萎缩性胃炎现患率在性别上基本保持一致,但在年龄分组上存在一定差异(P<0.05);(2)病例组二甲基甲酰胺接触率显著高于对照组,接触工龄≤5年者尤为突出(P<0.05);(3)调整吸烟、饮酒和其他职业病危害因素接触等混杂因素后,二甲基甲酰胺接触与患慢性非萎缩性胃炎的危险性增加显著相关,接触二甲基甲酰胺≤5年患慢性非萎缩性胃炎的危险较明显(P<0.05)。结论二甲基甲酰胺职业暴露可增加患慢性非萎缩性胃炎的危险。
Objective To study the association of dimethylformamide（DMF） exposure with chronic non-atrophic gastritis.Methods Firstly,a cross sectional survey was performed.385 workers from 4 factories were examined,among them 28 cases of chronic non-atrophic gastritis were found as case group.All the objects were sorted according to gender and age.1∶4 match principle was used in the study that was 4 controls/1 case in each sub-group,therefore,112 controls were selected.Additionally,Chi-square test and multivariable conditional logistic regression model were used for analysis and assessment of the association.Results（1） There was a similar prevalence of chronic non-atrophic gastritis in men and women;the prevalence was different with age（P〈0.05）.（2） The DMF exposure prevalence was significantly higher in case group.The major proportion of exposure duration were ≤5 years（P〈0.05）.（3） After adjusting the confounding factors such as smoking,drinking and other occupational exposure etc.the risk of chronic non-atrophic gastritis was obviously correlated to DMF exposure,especially the exposure less than 5 years（P〈0.05）.Conclusion The results suggested that DMF exposure may increase the risk of chronic non-atrophic gastritis.
出处
《苏州大学学报（医学版）》
CAS
2012年第4期466-470,共5页
Suzhou University Journal of Medical Science
关键词
二甲基甲酰胺
慢性非萎缩性胃炎
相关性
dimethylformamide（ DMF）
chronic non-atrophic gastritis
relevance
