摘要
目的对结肠靶向给药(CTDD)系统的相关进展全面综述,探讨其今后的发展方向,为研究人员提供参考与依据。方法查阅国内外19种期刊25篇相关文献,并进行分析、归纳。结果中药CTDD系统包括pH依赖型、时间依赖型、微生物酶解型、生物黏附型、压力依赖型、脉冲型和联合应用型。结论中药CTDD具有广阔的应用前景,但中药指标成分、体内评价等方面的研究还需加强。
Objective This review article is aimed at focusing the recent advances and the future direction on colon targeted drug de-livery （CTDD） system of traditional Chinese medicine. Methods 25 literatures from 19 journals were analyzed and summarized in this review. Results Traditional Chinese medicine CTDD system included pH-dependent, time-dependent, microbial enzyme-based, bio-adhesion type,pressure-dependent,pulse-type and combined type. Conclusions Traditional Chinese medicine CTDD has broad application prospects,but the indicator ingredients and evaluation methods in vivo need to be strengthened.
出处
《西北药学杂志》
CAS
2012年第5期487-489,共3页
Northwest Pharmaceutical Journal
基金
陕西省科技计划项目(编号:2011K16-04-01)
关键词
中药
靶向给药
结肠
traditional Chinese medicine
targeted drug delivery
colon
