摘要
目的通过对食管癌组织中Dlk-1蛋白表达的观察,探讨其临床意义。方法收集本院行食管癌根治术的食管癌标本,对食管癌及癌旁正常组织两组中Dlk-1蛋白的表达以免疫组织化学方法进行检测,并对Dlk-1蛋白表达与肿瘤分级及临床病理分期之间的相关性进行分析。结果 Dlk-1蛋白在食管癌组的表达与其在癌旁正常组织中的表达两者间存在显著的统计学差异(P<0.01)。食管癌组织中Dlk-1蛋白阳性表达与肿瘤临床病理分期呈正相关(P<0.01),与食管癌组织学分级负相关(P<0.01)。结论 Dlk-1蛋白的表达与食管癌的发生发展可能密切相关,将为食管癌的临床治疗及预后分析等提供新的思路。
Objective To explore the Dlk-1 protein expression in esophageal c arcinoma and analyze its clinical significance.Methods The expression of Dlk-1 p rotein was detected in 41 esophageal carcinoma tissues and 20 adjacent normal ti ssue by immunohistochemistry S-P method.The relationship between them was then analyzed.Results Dlk-1 protein was rarely seen in normal esop hageal tissues.T he positive expression of Dlk-1 protein in esophageal carcinoma was 58.53%.th e re was significant Statistically significant difference between the two groups.（ P〈0.05）.Dlk-1 protein expression in Esophageal cancer and tumor grade wer e re lated（P〈0.01）,and tumor stage was positively correlated（P〈0.01）.Conclusion The expression of Dlk-1 protein was significantly related with esophageal car cinoma,which could supply new ideas to the treatment and prognosis of esophageal carcinoma.
出处
《中国实验诊断学》
2012年第8期1440-1442,共3页
Chinese Journal of Laboratory Diagnosis
关键词
食管癌
Dlk-1
免疫组化
esophageal carcinoma
Dlk-1
immunohistochemistry
