摘要
目的对比观察达英-35、二甲双胍2者联用与达英-35单用对多囊卵巢综合征(PCOS)非胰岛素抵抗型患者的疗效。方法选取PCOS非胰岛素抵抗型患者126例,随机分为2组,各63例,分别应用达英-35及达英-35、二甲双胍联用治疗,观察2组治疗3个疗程后体重指数(BMI)、空腹胰岛素(FINS)、黄体生成素(LH)、促卵泡素(FSH)及睾酮(T)的改善情况。结果单用达英-35组治疗后BMI、FINS、LH、FSH水平均稍有降低,但较治疗前无明显改善,T水平与治疗前比较有显著降低。联合用药组治疗后BMI、FINS、LH、FSH及T水平较治疗前均下降明显。结论达英-35、二甲双胍能明显改善非胰岛素抵抗型PCOS体重指数及雄激素水平,是一种有效治疗方法。
Objective To compare the clinical efficacy between diane-35 combined with metformin and single application of diane-35 in non-insulin-resistant patients with polycystic ovary syndrome（PCOS）.Methods A total of 126 non-insulin-resistance patients with PCOS were selected and randomly divided into diane-35 group（n=63） and diane-35 combined with metformin group（n-63）.The changes of body mass index（BMI）,fasting insulin（FINS）,luteinizing hormone（LH）,follicle-stimulating hormone（FSH） and testosterone（T） in the two groups were observed after three courses of treatment.Results After treatment,the levels of BMI,FINS,LH and FSH were slightly lower in diane-35 group,but no significant improvement was observed.T level was significantly reduced.After treatment,the levels of BMI,FINS,LH and FSH in the diane-35 combined with metformin group were significantly decreased.Conclusion Diane-35 combined with metformin significantly improves BMI and androgen levels in non-insulin-resistant patients with PCOS with proved efficacy.
出处
《实用临床医药杂志》
CAS
2012年第15期103-104,107,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11220068)
