摘要
目的了解精神科门诊首发精神分裂症患者首次用药状况，为提高临床合理用药水平提供依据。方法将2000年1月-10月在我院精神科门诊治疗的180例首发精神分裂症患者设为A组，2010年1月-10月治疗的182例首发精神分裂症患者设为B组，对两组一般资料及用药状况进行调查分析。结果A组73．89％单用一种抗精神病药物治疗，26．11％联合用抗精神病药物治疗，12．78％预防性应用盐酸苯海索，25．56％联合应用苯二氮革类药物；B组93．96％单用一种抗精神病药物治疗，6．04％联合用抗精神病药物治疗，54．95％预防性应用盐酸苯海索，34．07％联合应用苯二氮革类药物。B组单用抗精神病药物频度显著高于A组（χ2=27．08，P〈0．01）。结论我院精神科门诊首发精神分裂患者单用一种抗精神病药物治疗频度明显增高，首次用药状况趋向合理，新型非典型抗精神病药已成为临床用药主流，但仍存在预防性用药现象。
Objective To investigate the first-time medicine usage status of first- episode schizophrenics at psychiatric outpatient service in order to provide basisfor improving clinical rational use level of drug. Methods A total of 180 first-episode schizophrenics trea- ted at psychiatric outpatient service of our hospital from Jan. to Oct. 2000 were assigned to group A and 182 ones from Jan. to Oct. 2010 to group B, their general information and medicine usage status were in- vestigated and analyzed. Results In group A 73.89 %of patients received single antipsychotic treatment, 26.11% did antipsychotic drug combination, 12. 78% did prophylactic benzhexol hydrochloride and 25. 56% did antipsychotics plus benzodiazepines; in group B 93. 96% of patients received single antipsy- chotic treatment, 6.04% did antipsychotic drugs combination, 54.95% did prophylactic benzhexol hydro chloride and 34.07%did antipsychotics plus benzodiazepine. The frequency of single-use antipsychotic was significantly higher in group B than in A （χ2=27.08, P〈0.01）. Conclusion The frequency of single-use antipsychotic treatment in first-episode schizophrenics heightened notably at psychiatric outpatient service of our hospital, first-time medicine usage status trends rationally, novel untypical antipsychotics become main trend of clinical medication, but prophylactic medication still remain.
出处
《临床心身疾病杂志》
CAS
2012年第5期428-430,477,共4页
Journal of Clinical Psychosomatic Diseases
关键词
精神科
门诊
首发精神分裂症
抗精神病药物
合理用药
单一用药
联合用药
Psychiatry department
outpatient service
first-episode schizophrenia
antipsychotics
ration-al use of drug
single drug
drug combination
