摘要
目的观察不同运动水平对新诊断肥胖T2DM患者代谢指标、胰岛功能及IS的影响。方法将74例新诊断肥胖T2DM患者随机分为强化运动组(强化组)及一般运动组(对照组),两组均予糖尿病知识健康教育、饮食管理、小剂量二甲双胍(0.5g/d);强化组运动200～250min/周,对照组运动100～150min/周。干预8周及16周后对两组血脂、血压、BMI、FBG、FIns、FC-P、HbA1c、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)及胰岛素初期相分泌指数(△I30/△G30)进行比较。结果干预8周后强化组TG、TC、HbA1c、HOMA-IR明显低于对照组(P<0.05或P<0.01);16周后强化组0min及60min血糖、TG、DBP、BMI、HbA1c,以及HOMA-IR明显低于对照组(P<0.05或P<0.01);HDL-C、FC-P及HOMA-β明显高于对照组(P<0.05或P<0.01)。结论新诊断肥胖T2DM患者通过增加运动量有益于代谢指标及胰岛功能的进一步改善。
Objective To investigate the effects of different exercise intensities on metabolism, ^-cell function, and insulin sensitivity （IS） in newly diagnosed obese T2DM patients. Methods Seventy-four newly diagnosed obese T2DM patients were randomized into two groups： treated with exercise for 200-250 minutes per week （intensive group） and for 100-150 minutes per week （control group） respectively. Both groups were given diabetes propaganda, diabetic diet management, and small dose of metformin （0. 5 g/d）. The values of blood lipid, blood pressure, BMI, FBG, Fins, FC-P, HbAlc, HOMA-IR, HOMA-β, and △I30/△G30 were determined and compared after 8 and 16 weeks＇ treatment. Results Compared with the control group, the level of TG, TC, HbA1 c, and HOMA-IR were decreased signifi- candy in the intensive physical activity group （P〈0.05 or P〈0.01） after 8 weeks. After 16 weeks, the OGTT test was performed and the glucose level at 0 rain and 60 min in the intensive physical activity group were significantly lower than in the control group （P^0. 05 or P^0. 01） ; the level of TG, DBP, BMI, HbAlc, and HOMA-IR were significantly lower （P〈0.05 or P〈0.01）, however, the level of HDL-C, FC-P, and HOMA-β were increased significantly （P〈0.05 or P〈0. 01） compared with the control group （P〈0. 05 or P〈0. 01）. Conclusions Increasing the intensity of physical activity will be beneficial to the improvement of metabolism indices and β-cell function in newly diagnosed T2DM patients.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2012年第9期663-666,共4页
Chinese Journal of Diabetes
关键词
糖尿病
2型
运动治疗
代谢指标
Β细胞功能
Diabetes mellitus, type 2
Physical therapy
Metabolism indices
Islet
cell function
