期刊文献+

亲水作用色谱串联质谱同时检测食品接触产品中三聚氰胺和三聚氰酸单体迁移量 被引量:6

Simultaneous Determination of Melamine and Cyanuric Acid in Food Contact Packaging Materials by Hydrophilic Liquid Chromatography-Tandem Mass Spectrometry
下载PDF
导出
摘要 建立一种亲水作用色谱串联质谱技术同时检测食品接触产品中三聚氰胺与三聚氰酸单体迁移量的方法。样品采用水、体积分数4%乙酸溶液、体积分数10%乙醇溶液、异辛烷和橄榄油模拟物进行浸泡。在优化色谱及质谱条件下三聚氰胺和三聚氰酸能很好分离,且分别在1~100ng/mL和2~200ng/mL范围内,峰面积和质量浓度线性关系良好。在50ng/mL添加回收实验结果表明,三聚氰胺和三聚氰酸的平均回收率分别为86.2%~134.0%和78.9%~156.0%,相对标准偏差分别为6.44%~17.93%和5.95%~11.78%。该法简便、快速、准确,可同时测定食品接触产品中三聚氰胺与三聚氰酸单体迁移量。 An HILC-MS/MS method was developed to simultaneously determine melamine and cyanuric acid in food contact packaging materials. Samples were extracted with 1-120, 4% acetic acid (V/V), 10% ethanol isooctane (V/V) and olive oil separately, kept in a 70 ℃ incubator for 2 h and then filtered through a 0.2 μm microporous membrane prior to injection into an HILC-MS/ MS system. Melamine and cyanuric acid were separated, identified and quantified on HILC column by gradient mobile phase and monitored in a positive/negative electrospray ionization and multiple reaction monitor (MRM) mode. A good linear range was achieved over the concentration range of 1 -- 100 ng/mL and 2 -- 200 ng/mL for melamine and cyanuric acid in different stimulants, respectively. The limits of detection and limits of quantification were in the range of 0.4--0.8 ng/mL. The recovery rates of melamine and cyanuric acid were 134.0% --86.2% and 156.0%- 78.9% with RSDs of 6.44% -- 17.93% and 5.95%- 11.78%. This method was simple, rapid, and accurate, and suitable for the determination of melamine and cyacuric acid in food contact packaging materials.
出处 《食品科学》 EI CAS CSCD 北大核心 2012年第16期159-162,共4页 Food Science
基金 福建省科技计划重点项目(2009Y0001) 国家质量监督检验检疫总局2011年度科技计划项目 福建出入境检验检疫局科技计划项目(FK2010-22)
关键词 亲水作用色谱串联质谱 食品接触产品 三聚氰胺 三聚氰酸 迁移 HILC-MS/MS food contact packaging materials melamine cyanuric acid migration
  • 相关文献

参考文献13

  • 1CARBAS P, MELONI M, SPANEEDDA L. High-performance liquid chromatographic separation of cyromazine and its metabolite melamine [I]. Journal of Chromatography, 1990, 505(2): 413-416.
  • 2LORI O L, SUSAN J S, KENNETH D S, et al. Disposition of cyromazine in plants under environmental conditions[J]. J Agric Food Chem, 1990, 38(3): 860-864.
  • 3KIRK O. Encyclopedia of chemical technology[M]. 4th. New York : John Wiley & Sons, 1993: 834-851.
  • 4KOWALSKY L. Certified pool-SPA operator[M]. Taxas: National Swim- nng Pool Fundation, 1992: 46.
  • 5World Health Organization (WHO). Expert meeting to review toxico- logical aspects of melamine and eyanuricaeid [EB/OL]. (2008-11-01) http://www.who.int/foodsafety/fs_management/ conclusions__recommendations.pdf.
  • 6JUTZIK, COOK A M, HU'I'I'ER R. The degradative pathway of the s- triazine melamine. The steps to ring cleavage[J]. Biochemistry Journal, 1982, 208(3): 679-684.
  • 7SHELTON D R, KARNS J S, MCCARTY G W, et al. Metabolism of melamine by Klebsiella terragena[J]. Applied Environmental Microbiolo,v, 1997, 63(7): 2832-2835.
  • 8李锋格,姚伟琴,苏敏,李世雨,窦辉,尚德军,朱慧萍.气相色谱-质谱法快速测定牛奶中的三聚氰胺和三聚氰酸[J].色谱,2009,27(2):233-236. 被引量:47
  • 9LUND K H, PETERSEN J H. Migration of formaldehyde and melamine monomers from kitchen-and tableware made of melamine plastic[J]. Food Additives and Contaminants, 2006, 23(9): 948-955.
  • 10WANG Xiaoyu, CHEN Yi. Determination of aromatic amines in food products and composite food packaging bags by capiUary electrophoresis couplod with transient isotachophoretie stacking[J]. Journal of Chroma- tography A, 2009, 1216(43): 7324-7328.

二级参考文献39

  • 1栾伟.液相色谱串联质谱法(LC-MS/MS)分析宠物食品中三聚氰胺[J].分析测试学报,2007,26(z1):285-286. 被引量:39
  • 2Yokley R A, Mayer L C, Rezaaiyan R, et al. J Agric Food Chem, 2000, 48:3 352
  • 3Sancho J V, Ibafiez M, Grimalt S, et al. Anal Chim Acta, 2005, 530 : 237
  • 4中华人民共和国卫生部、工业和信息化部、农业部、国家工商行政管理总局、国家质量监督检验检疫总局.中华人民共和国卫生部、工业和信息化部、农业部、国家工商行政管理总局、国家质量监督检验检疫总局公告:2008年第25号.
  • 5Ministry of Health, Ministry of Industry and information Technology, Ministry of Agriculture, State Administration for Industry and Commerce, General Administration of Quality Supervision, Inspection and Quarantine of the People' s Republic of China. Bulletin issued by Ministry of Health, Ministry of Industry and information Technology, Ministry of Agriculture, State Administration for Industry and Commerce, General Administration of Quality Supervision, Inspection and Quarantine of the People ' s Republic of China: No. 25, 2008. [2008-10-08 ]. http://www. aqsiq. gov. cn/zjxw/zjxw/zjft pxw/200810/t20081008_92610.htm
  • 6Cantu R, Evans O, Magnuson M L. Chromatographia, 2001, 53(7/8) : 454
  • 7Puschner B, Poppenga R H, Lowenstine L J, et al. J Vet Diagn Invest, 2007, 19(5) : 615
  • 8WHO. Melamine and cyanuric acid: toxicity, preliminary risk assessment and guidance on levels in food. [ 2008-09- 25 ]. http://www. who. int/entity/foodsafety/fs _ management/infosan_events/en/index. html
  • 9Reimschuessel R, Gieseker C M, Miller R A, et al. AJVR, 2008, 59(9) : 1 217
  • 10Brown C A, Jeong K S, Poppenga R H, et al. J Vet Diagn Invest, 2007, 19:525

共引文献68

同被引文献76

引证文献6

二级引证文献75

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部