摘要
目的探讨奥曲肽与奥美拉唑治疗消化性溃疡致上消化道出血的疗效、不良反应及成本-效果。方法将2009年1月至2010年12月消化性溃疡致上消化道出血患者106例随机分为奥美拉唑组和奥曲肽组。奥美拉唑组患者给予注射用奥美拉唑钠40 mg静脉滴注,每天2次;奥曲肽组患者先用100μg醋酸奥曲肽注射液+0.9%氯化钠注射液20 mL缓慢静脉注射,然后将100μg醋酸奥曲肽注射液加入250 mL 0.9%氯化钠注射液中维持静脉滴注(25μg/h)。两组患者均治疗5 d,分析成本效果。结果两组患者总有效率比较,差异无统计学意义(P>0.05);获得1个单位效果情况下,奥曲肽组所用成本小于奥美拉唑组,差异有统计学意义(P<0.05)。结论奥曲肽组静脉滴注方案,临床效果显著,成本相对更低,值得临床推广。
Objective To investigate the differences in the effects,adverse reactions and the cost-effectiveness ratio of octreotide and omeprazole for treating upper gastrointestinal hemorrhage.Methods 106 patients with upper gastrointestinal hemorrhage were selected from January 2009 to December 2010 and divided into two groups,the omeprazole group and octreotide group.The omeprazole group was given omeprazole 40 mg by intravenous drip,twice a day.The octreotide group was given octreotide 100 μg adding to normal saline 250 mL by slowly intravenous injection,then octreotide 100 μg adding to normal saline 250 mL by maintenance intravenous drip（25 μg/h）.All cases were treated for 5 d.The cost-effectiveness was analyzed in the two groups.Results The total effective rates in the two groups were not different（P 〉 0.05）.On the condition of obtaining 1 unit of effect,the cost in the octreotide group was less than that in the omeprazole group with statistical difference between them（P 〈 0.05）.Conclusion The clinical effect of the intravenous drip regimen in the octreotide group is remarkable with small cost.
出处
《中国药业》
CAS
2012年第16期71-72,共2页
China Pharmaceuticals
关键词
上消化道出血
成本-效果分析
奥美拉唑
奥曲肽
upper gastrointestinal hemorrhage
cost-effectiveness
omeprazole
octreotide
