摘要
目的研究雌激素受体(ER)、孕激素受体(PR)在不孕症子宫内膜息肉(EP)组织中的表达,探讨其与宫腔镜术后妊娠状况的关系。方法采用逆转录-聚合酶链反应(RT-PCR)检测106例子宫内膜息肉组织中ER mRNA、PR mRNA表达,以宫腔镜术后3～6个月是否妊娠分为两组:妊娠组与非妊娠组,比较两组间术前子宫内膜息肉组织中ER mRNA、PR mRNA表达差异,并进行分析。结果妊娠组ER mRNA的表达低于非妊娠组,但差异无统计学意义(P>0.05);PR mRNA在妊娠组的表达显著高于在非妊娠组中的表达,差异有统计学意义(P<0.05);非妊娠组中的复发病例组,其息肉组织中ER mRNA表达显著高于非复发组及妊娠组(P<0.05),而PR mRNA在复发组的表达低于非复发组的表达,差异有统计学意义(P<0.05)。结论 PR在EP中的低表达可能是宫腔镜术后仍不孕的因素之一;PR在EP中的低表达及ER的高表达与EP宫腔镜术后复发密切相关。
Objective To investigate the expression of estrogen reeeptor（ER） and progesterone receptor（PR） in ectomy of endometrial polyps（EP）, and to explore their effects to pregnancy after treatment by hysteroscropy. Method 106 cases of EP were obtained from the patients who underwent a surgical trestment by hysteroscopy.ER and PR were examined by semi-quantitative reverse transcription-polymerase chain reaction（RT-PCR） in 106 cases of EP. Result The mRNA of ER was lower in pregnancy group than that in non-pregnancy group （P〉0.05）.PR mRNA level were notedly higher in pregnancy group than that in non-pregnancy group （P〈0.05）.In relapse group of non-pregnancy group, ERmRNA was significantly higher than that in pregnancy group and non-relapse group（P〈0.05）, and PRmRNA was significantly lower than that in pregnancy group and non-relapse group（P〈0.05）. Conclusion Lower PRmRNA level and higher ERmRNA level may be related to pregnancy failing and may be one of the cause for EP relapse after after treatment by bysteroscropy,
出处
《中国医药指南》
2012年第24期439-440,共2页
Guide of China Medicine
关键词
子宫内膜息肉
雌激素受体
孕激素受体
宫腔镜
妊娠
Ectomy of endometrial polyps
Estrogen receptor
Progesterone receptor
Hysteroscopy
Pregnancy
