摘要
目的:探讨注射用奥美拉唑治疗胃溃疡出血的临床效果。方法:将90例胃溃疡出血患者随机分为两组各45例。观察组予以注射用奥美拉唑40mg+生理盐水100ml中静脉滴注,2次/d,疗程3d;对照组予以西咪替丁800～1200mg+酚磺乙胺每日静点,疗程3d;比较两组止血效果。结果:观察组及对照组临床治疗总有效率分别为91.1%(41/45)、71.1%(32/45),两者差异有统计学意义(P<0.05);观察组和对照组的止血时间分别为(7.3±2.4)d,(9.4±2.7)d,差异有统计学意义(P<0.05)。观察组溃疡愈合总有效率显著高于对照组,差异有统计学意义(P<0.05)。两组患者在治疗过程中血常规、肝功能及肾功能均无异常改变,观察组及对照组副反应发生率分别为2.2%(1/45)、13.3%(6/45),两者差异有统计学意义(P<0.05)。结论:注射用奥美拉唑对胃溃疡出血止血效果良好,对提高临床疗效、改善预后均有显著作用。
Objective：To investigate the clinical efficacy of injection of Omeprazole on gastric ulcer bleeding.Methods：90 patients with gastric ulcer bleeding were divided into two groups.The observation group（45 cases） were injected with Omeprazole 40mg ＋ 100ml normal saline intravenously,2 times/d,treatment for 3d;the control group（45 cases） were treated with Cimetidine 800~1200mg＋ Ethamsylate,treatment for 3d;the effect of two groups of patients stop bleeding were compared.Results： The total effect rate of the observation group and control group were 91.1%（41/45） and 71.1%（32/45） respectively,there was statistical difference（P〈0.05）.Hemostatic time of the observation group and control group were（7.3±2.4） d and（9.4±2.7） d respectively,there was statistical difference（P〈0.05）.The total effective rate of ulcer healing in observation group were significantly better than that in control group,there was statistical difference（P〈0.05）.During treatment,two groups of blood routine,liver and kidney function had no abnormal changes,incidence rate of side effects were 2.2%（1/45） and 6.7%（3/45） respectively,there was statistical difference（P〈0.05）.Conclusion：Injection of omeprazole on gastric ulcer bleeding patients had better hemostatic effect,had positive role in improving the clinical efficacy and the prognosis.
出处
《中国民康医学》
2012年第16期1931-1933,共3页
Medical Journal of Chinese People’s Health
关键词
奥美拉唑
胃溃疡
出血
止血
Omeprazole； Gastric ulcer； Bleeding； Hemostatic
