摘要
目的:探讨慢性肾脏病(CKD)患者血清甲状腺激素的变化规律。方法:采用放射免疫法测定120例不同分期的慢性肾脏病患者甲状腺功能并与30例健康者进行对照分析。同时比较20例CKD 5期患者中重危者、病情稳定者与对照组的TT4差异。结果:CKD 3期、4期、5期患者中TT3、FT3均低于对照组,r-T3均高于对照组,TT4在重危者中明显低于对照组。结论:CKD患者随着病情加重,TT3、FT3逐渐下降,病情危重者TT4亦下降,TT4下降是患者预后不良的标志。
Objective：To investigate the changes of serum thyroid hormone and the related clinical significance in patients with chronic kidney disease（CKD）.Methods：One hundred and twenty CKD patients and 30 healthy controls were enrolled in this study.The CKD patients included 20 severe or steady CKD patients with stage 5.The thyroid functions of all subjects were performed and analysized.Results：The levels of serum TT3 and FT3 in CKD patients with stage 3~5 were significantly lower than those in the control group,but serum r-T3 was higher than the figure in the control grounp.Moreover,the level of TT4 in severe CKD patients with stage 5 was significantly lower than that in the control group.Conclusion：The levels of serum TT3 and FT3 of CKD patients gradually decrease along with the CKD condition deteriorating,TT3,FT3,and TT4 also drops in severe CKD condition.The serum TT4 decrease is a predictive marker of the bad prognosis in CKD patients.
出处
《中国民康医学》
2012年第16期1934-1935,1939,共3页
Medical Journal of Chinese People’s Health
关键词
慢性肾脏病
甲状腺激素
Chronic kidney disease； Thyroid hormone
