摘要
目的:观察利培酮和阿立哌唑治疗首发精神分裂症的临床疗效以及对血糖、血脂的影响。方法:将78例首发精神分裂症患者随机分为利培酮组38例和阿立哌唑组40例,治疗8周。均采用阴性和阳性症状量表评定临床疗效,副反应量表评定不良反应,并测定空腹血糖、总胆固醇、甘油三酯的变化。结果:两组临床疗效、阳性和阴性症状量表评分差异无显著性(P﹥0.05);阿立哌唑组副反应量表评分明显低于利培酮组(P<0.01);利培酮组总胆固醇、甘油三酯水平较治疗前明显增高(P<0.01),阿立哌唑组治疗前后比较差异无显著性(P>0.05)。结论:利培酮与阿立哌唑治疗首发精神分裂症疗效相当,阿立哌唑不良反应以及对血糖、血脂的影响小于利培酮。
Objective:To observe the efficacy of Risperidone and Aripiprazole in first-episode schizophrenia and effects on blood glucose and lipid.Methods:Seventy-eight first-episode schizophrenia patients were randomly assigned to Risperidone group(n=38) and Aripiprazole group(n=40),treated for 8 weeks.Efficacies were assessed with the Positive and Negative Syndrome Scale(PANSS),adverse reactions with the Treatment Emergent Symptom Scale(TESS) and changes of fasting glucose(Glu),total cholesterol(TC) and triacylglycerol(TG) detected.Results:There were no significant differences in the PANSS scores(P〉0.05);the score of the TESS in Risperidone group was significantly lower than that in Aripiprazole group(P〈0.01);TC and TG levels heightened notably after treatment compared with pre-treatment in Risperidone group(P〈0.01),and there were no significant differences between pre-treatment and post-treatment in Aripiprazole group(P〉0.05).Conclusion:Risperidone and Aripiprazole have equivalent efficacy in first-episode schizophrenia,but Risperidone has an advantage in adverse reactions,blood glucose and lipid over Aripiprazole.
出处
《中国民康医学》
2012年第16期1944-1945,1987,共3页
Medical Journal of Chinese People’s Health
基金
中山市医学科研基金项目(2008129)
关键词
利培酮
阿立哌唑
首发精神分裂症
糖代谢
脂代谢
Risperidone; Aripiprazole; First-episode schizophrenia; Glucose metabolism; Lipid metabolism