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合用阿立哌唑可减轻奥氮平治疗所致精神分裂症患者血脂水平升高 被引量:29

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摘要 目的对比阿立哌唑口腔崩解片与奥氮平合用及单用奥氮平对精神分裂症患者空腹血糖、血脂的影响。方法将符合入组标准的70名精神分裂症患者随机分为研究组及对照组,完成研究62例,奥氮平合用阿立哌唑口腔崩解片(10mg/d)组30例(研究组),单用奥氮平组32例(对照组)。对比组内及组间基线及治疗6周后空腹血糖、甘油三酯、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的变化情况。结果研究组组内治疗前后对比,其空腹血糖(4.75±0.48 vs.5.07±0.48)、甘油三酯(1.12±0.30 vs.1.41±0.30)、总胆固醇(4.44±0.70 vs.4.65±0.74)、LDL-C(2.39±0.45 vs.2.57±0.48)(单位均为mmol/l,下同)水平均有显著升高(P<0.05)。同样,对照组组内治疗前后对比,其空腹血糖(4.86±0.44 vs.5.13±0.36)、甘油三酯(0.97±0.31 vs.1.42±0.44)、总胆固醇(4.56±0.80 vs.4.96±1.09)、LDL-C(2.28±0.79 vs.2.62±0.69)水平也均有显著升高(P<0.05)。两组间比较,研究组甘油三酯(0.28±0.17 vs.0.45±0.40)、LDL-C(0.18±0.20 vs.0.34±0.33)水平升高值较对照组小(P<0.05)。结论合用阿立哌唑能够明显减轻奥氮平升高血脂的作用,但对血糖变化无影响。
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2012年第9期551-553,共3页 Chinese Journal of Nervous and Mental Diseases
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