摘要
目的分析53例胰肾联合移植长期存活情况及其影响因素。方法回顾性分析2000年1月至2009年6月间施行的53例胰肾联合移植受者和移植物长期存活情况，分析受者死亡原因和移植物功能丧失原因。结果3、5和8年受者存活率分别为90．1％、89．1％和80．0%，3、5和8年移植胰腺存活率分别为84．9％、84．S％o和60．0％，3、5和8年移植肾存活率分别为83．O％、82．6％和53．3％。受者死亡原因分别为感染（4例）、移植肾功能丧失（2例）、心血管急症（1例）和脑卒中（1例）。移植胰腺功能丧失的主要原因为带功能受者死亡、排斥反应和外科并发症。移植肾功能丧失的主要原因为排斥反应和带功能受者死亡。结论胰肾联合移植治疗终末期糖尿病肾病远期效果良好，感染、排斥反应和外科并发症是受者死亡和移植物功能丧失的主要原因。
Objective To determine the long-term results after combined pancreas-kidney transplantation at a single-center institution. Methods Fifty-three consecutive patients with insulin-dependent diabetes rnellitus and end stage nephropathy were followed up for more than three years after combined pancreas-kidney transplantation. Imrnunosuppressive protocol consisted of taerolimus （ TAC ）, rnycophenolate mofetil （MMF）, and steroids, and antithymocyte globulin or anti-CD25 receptor mAh. The impact of different risk factors was analyzed on long-term patient and graft survival. Results The 3-,5- and 8-year survival rate in recipients was 90. 1%, 89. 1% and 80. 0%, respectively. The 3-, 5- and 8-year survival rate of pancreas grafts was 84. 9%, 84. 80% and 60. 0%, and that of kidney grafts was 83. 0%, 82. 6% and 53. 3%, respectively. Principal causes of death were Infection （n = 4）, renal failure （n = 2）, cardiovascular events （n = 1）, and eerebrovascular accident （n = 1 ）. Graft failure for the pancreas was caused by death with a functioning graft （n = 6）, rejection （n = 2）, thrombosis （n = 1） and pancreatitis （n = i）. Graft failure for the kidney was due to rejection （n = 9）, and death with a functioning graft （n = 9）. Conclusion This series representing the largest experience with long-term follow-up in China confirms an excellent long-term survival. Infection, rejection and surgical complication were the major risk factors leading to deaths and graft loss.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2012年第9期523-527,共5页
Chinese Journal of Organ Transplantation
基金
国家高技术研究发展计划（863计划）项目（2012AA（121010）
关键词
糖尿病
胰腺移植
肾移植
排斥反应
长期存活
Diabetes mellitus
Pancreas transplantation
Kidney transplantation
Rejection
Long-term survival
