摘要
以α-溴代酮、硫脲和乙酸酐为原料,微波辐射下一锅法合成了8种2-乙酰氨基噻唑衍生物.该方法反应时间短、操作简单、后处理方便.目标化合物的结构通过1H NMR,IR和元素分析进行了表征.实验证明部分目标化合物具有良好的抑菌活性.
An efficient one-pot method is used to prepare a series of 2-acetamide-thiazole derivatives from a-bromoketone, thiourea and acetic anhydride under microwave irradiation. The reaction procedures have the advantages of easy work up, short time and simple operation. The products were identified by 1H NMR and IR spectra and elemental analysis. These compounds exhibit good antimicrobial activities.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2012年第9期1746-1748,共3页
Chinese Journal of Organic Chemistry
基金
河北省教育厅计划(No.2009435)
河北农业大学非生命学科和新兴学科基金(No.2009020)资助项目~~
关键词
微波
一锅法合成
2-乙酰氨基噻唑衍生物
抑菌活性
microwave irradiation
one-pot synthesis
2-acetamide-thiazole derivatives
biological activity
