摘要
以廉价的异香草醛和2,4,6-三羟基苯乙酮为起始原料,经过C-异戊烯基化、环化、选择性的保护酚羟基、羟醛缩合、催化环化等步骤,脱保护基,以6.7%的总收率首次完成了天然吡喃型黄烷酮(±)-5,3'-二羟基-7,8-(2,2-二甲基吡喃)-4'-甲氧基黄烷酮的全合成.所有新化合物的结构都经过IR,1H NMR,MS,HRMS确认.
The total synthesis of （±）-5,3＇-dihydroxy-4＇-methoxy-6＂,6＂-dimethyl-chromeno-（7,8,2＂,3＂）-flavanone was first achieved through C-prenylation, cyclization, selective protection of phenolic hydroxyl group, aldol condensation, cyclization and deprotection starting from cheap isovanillin and 2,4,6-trihydroxyacetophenone, with total yield 6.7%. All structures of new compounds were confirmed by 1R, ^1H NMR, MS and HRMS techniques.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2012年第9期1749-1752,共4页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.20962016
21162021)
教育部新世纪优秀人才支持计划(No.NCET-09-0860)
宁夏自然科学基金(No.NZ1006)资助项目~~
