摘要
目的探讨纤维支气管镜检查及活检对诊断早期支气管黏膜内微小肺癌的优越性。方法回顾性分析1993年1月至2008年12月经纤维支气管镜检查、活检病理确诊,再经手术切除,直径在0.5～1.0cm的早期支气管黏膜内微小肺癌患者107例临床资料(观察组),同期选择手术切除,直径大于2cm的中、晚期肺癌107例临床资料(对照组),两组患者术后出院随访,观察其预后。结果观察组中87例黏膜内微小肺鳞状细胞癌和11例黏膜内微小肺腺癌患者术后3～5年均健在,其中56例随访6～10年健在。9例黏膜内微小肺小细胞癌(SCLC)术后4～6年因肿瘤复发或转移致死。对照组中,87例肺鳞状细胞癌和11例肺腺癌患者术后1～2年生存者67例,3～5年生存者22例;9例SCLC患者术后均在2年内因肿瘤复发或转移致死。结论纤维支气管镜检查及活检是早期发现支气管黏膜内微小肺癌的有效手段,尤其对于存在高危因素的患者应定期检查,早期诊断和及时手术治疗是提高患者生存期最重要的因素。
Objective To investigate the superiority of the fibrobronchoscopy and biopsy on diagnosis of early bronchial intramueosal minimal lung cancer. Methods To perform the retrospective analysis on the clinical data in 107 cases （observation group） of early bronchial intramucosal minimal lung cancer diagnosed by fibrobronchoseopy and biopsy, resected by operation and 0.5-1.0cm in diameter from January 1993 to December 2008,and at the same period 107 cases（control group） of medium and ad- vanced lung cancer resected by operation and ~ 2cm in diameter. The two groups were followed up for observing prognosis. Results In the observation group,87 cases of intramucosal minimal lung squamous cell carcinoma and 11 cases of intramucosal minimal lung adenocarcinoma were still survival in 3--5 years after operation. Among them, 56 cases were still survival with good heath in postoperative 6-- 10 years. 9 cases of intramucosal minimal lung small cell carcinoma died of recurrence and metastasis in postopera- tive 4--6 years. In the control group,among 87 cases of lung squamous cell carcinoma and 11 cases of lung adenocarcinoma,67 cases were survival in postoperative 1--2 years,22 cases were survival in in postoperative 3--5 years were survival. 9 cases of lung small cell carcinoma died of recurrence and metastasis within postoperative 2 years. Conclusion Fiberoptic bronchoscopy and biopsy are effective methods for early detecting bronchial intramucosal minimal lung cancer. Especially the patients with high risk factors should be regularly examined. Early diagnosis and timely surgical operation are most important factors to increase the survival peri- od of lung cancer patient.
出处
《重庆医学》
CAS
CSCD
北大核心
2012年第27期2836-2838,F0003,共4页
Chongqing medicine
