期刊文献+

姜黄素诱导肺癌细胞凋亡机制的研究进展 被引量:1

下载PDF
导出
摘要 姜黄素作为一种传统中药,以其毒性低、耐受性好、药理作用广泛等特点日益受到广泛关注。其中抗肿瘤作用已被大量的动物实验及体外细胞实验研究所证实。对于不同组织、不同来源的肿瘤细胞,其发挥抗肿瘤作用的机制也不尽相同,本文就姜黄素诱导肺癌细胞凋亡的主要机制做一简要综述。
出处 《中国医药指南》 2012年第25期85-86,共2页 Guide of China Medicine
  • 相关文献

参考文献17

  • 1Wong BC,Jiang X,Fan XM,et al.Suppression on Rel A/P65nuclear translocation independent of Ikappa-alpha degradation by cycloo-xygenase-2inhibitor in gastric cancer[J].Oncogene,2003,22(8):1189-1197.
  • 2Sasaki N,Morisaki T,Hashizume K,et al.Nuclear factor kappa Bp65(RelA)transcription factor is constitutively activated in human gastric carcinoma tissue[J].Clin Cancer,2001,7(12):4136-4142.
  • 3Biswas SK,McClure D,Jimenez LA,et al.Curcumln induces glutathione blosynthesis and inhibits NF-kB activation and interleukin-8release in alveolar ePithelial cells.Mechanism of free radlcal scavenging activity[J].Antloxd Redox Slgnal,2005,7(1-2):32-41.
  • 4黄冬生,陈金和,陈楚林.半胱氨酸蛋白酶8在姜黄素诱导人肺癌细胞凋亡中的作用[J].华中医学杂志,2003,27(1):9-10. 被引量:4
  • 5Ji H,Wang Z,Perera SA,et al.Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models[J].Cancer Res,2007,67(10):4933-4939.
  • 6Vicent S,Garayoa M,Lopez-Picazo JM,et al.Mitogen-activated protein kinase phosphatase-1is overexpressed in non-small cell lung cancer and is an independent predictor of outcome inpatients[J].Clin Cancer RES,2004,10(11):3639-3649.
  • 7de Melo M,Gerbase MW,Curran J,et al.Phosphorylated extrace-llular signal-regulated kinases are significantly increased in malignant mesothelioma[J].J Histochem Cytochem,2006,54(8):855-861.
  • 8李子广,王恩举,刘兆阳,吴华璞.ERK1/2在姜黄素对肺癌A549细胞增殖抑制中的作用[J].蚌埠医学院学报,2011,36(3):231-234. 被引量:2
  • 9Ambrosini G,A dida C.A novel anti-apoptosis gene Survivin,expre-ssed in cancer and lymphoma[J].Nat Med,1997,3(8):917-921.
  • 10Dohi T,Beltrami E,Wall NR,et al.Mitochondrial surviving inhibits apoptosis and promotes tumorigenesis[J].J Clin Invest,2004,114(8):1117-1127.

二级参考文献47

  • 1傅涛,徐永华.细胞凋亡的信号转导研究进展[J].细胞生物学杂志,1996,18(4):153-157. 被引量:15
  • 2吕中强,王益民,曹延延,张庆俊,张祥宏,李月红,王恒树,解慧玲,焦保华,张健慧.基质金属蛋白酶3、7基因多态性与脑星形胶质细胞瘤发病风险的关系[J].癌症,2007,26(5):463-468. 被引量:7
  • 3GRADHAKRISHNAPILLAI,ANANDSSRIVASTAVA,TAREKJ HASSANEIN, et al. Induction of apoptosis in human lung cancer cells by curcumin[J]. Cancer Lett,208(2004) : 163-170.
  • 4KUO ML, HANG TS, LIN JK. Curcumin,an antioxidant and antitumor promoter ,induces apoptosis in human leukemia ceils [J]. Biochim Biophys Acta, 1996,1317 ( 2 ) : 95.
  • 5LI F, AMBROSINI G, CHU EY, et al.Control of apoptosis and mitotic spindle checkpoint by surviving[J].Nature, 1998,396 (6711 ) : 580- 584.
  • 6BUSH JA,CHEUNG KJ,LI GANG,et al. Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53 [ J ]. Exp Cell Res, 2001,271 (2) : 305-314.
  • 7AMBROSINI G,ADIDA C,SIRUGO G,et al.Induction of apoptosis and inhibition of cell proliferation by surviving gene targeting [J]. J Biol Chem, 1998,273(18) : 11177-11182.
  • 8Kawasaki H, Altieri DC, Lu CD, et al. Inhibition of apoptosis by Survivin predicts shorter survival rates in colorectal cancer. Cancer Res, 1998 ,Nov 15 ;58(22) :5071 -4.
  • 9Ambrosini G, Adida C, Altieri DC, et al. A novel anti-apoptosis gene Survivin, expressed in cancer and lymphoma. Nat Med, 1997,3:917 -21.
  • 10Akyurek N, Mends L, Ekinci O, et al. Survivin expression in preinvasive lesions and non-small cell lung carcinoma. Virchows Arch, 2006, 449(2) : 164 - 170.

共引文献34

同被引文献23

  • 1Campbell M,Freeman JV.Survival statistics[J].Br JGen Pract,2007,57 (538):410.
  • 2FONG KM,SEKIDO Y,GAZDAR AF,et al. Lung cancer. Mole-cular biology of lung cancer:clinical implications[J].Clin Chest Med,2011,32(4):703-740.
  • 3马文丽,郑文岭.分子胂瘤学[M].北京.科学出版社,2003:123-127.
  • 4Enari M, Sakahira H,Yokoyama H, et al. A caspase-ac-tivated DNase that degrades DNA during apoptosis, andits inhibitor ICAD[J]. Nature, 1998, 391(6662); 43-50.
  • 5Sakahira H,Enari M,Nagata S.Cleavage of CAD in-hibitor in CAD activation and DNA degradation dur-ing apoptosis [J].Nature, 1998,391(6662):96-99.
  • 6Berridge MJ, Bootman MD,Lipp P. Calcium-a life anddeath signal [J]. Nature, 1998,395 (6703): 645-648.
  • 7Verhagen AM,Eckert PG,Paunch M, et al.Identifica-tion of DIABLO, mammalian protein that promotes ap-optosis by binding to and antagonizing IAP proteins[J].Cell,2000,102 (1):43-53.
  • 8Sutherland LC,Wang K,Robinson AG. RBM5 as a putativetumor suppressor gene for lung cancer [J]. Jou malof Thoracic Oncology,2010,5 (3):294-298.
  • 9Ramaswamy S,Ross KN,Lander ES,et al. A molecularsignature of metastasis in primary sol id tumors[J].Nat Genet,2003,33(1):49-54.
  • 10Oh JJ,Razfar A. ,Delgado I,et al. 3p21. 3tumor sup-pressor gene h37/lucal5/RBM5 inhibits growth ofhuman lung cancer cells through cell cycle arrestand apoptosis [J].Cancer Res,2006,66 (7):3419-3427.

引证文献1

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部