摘要
目的了解入伍新兵呼吸道合胞病毒(RSV)IgG抗体水平,为预防RSV感染提供科学依据。方法采用血清流行病学调查方法,利用酶联免疫吸附试验(ELISA),对随机抽取的2001～2008年364名入伍新兵血清进行RSVIgG抗体检测,并进行统计分析。结果 364名新兵血清RSV抗体阳性57人,阳性率15.66%;2001～2008年各年度阳性率6.52%～28.89%,差异有统计学意义(χ2=21.006,P<0.05);被调查新兵来自16个省市,其中天津(47.83%)、广西(39.13%)、山东(34.78%)和甘肃(21.74%)来源新兵RSV抗体阳性率较高,其余省市相对较低,差异有统计学意义(χ2=72.323,P<0.05);入伍前工作与否者抗体阳性率差异无统计学意义(χ2=0.170,P>0.05)。结论入伍新兵RSV抗体水平较低,且存在显著的地区和年度差异,应引起高度重视。
Objectives This study was conducted to investigate the distribution of respiratory syncytial virus（RSV） antibody IgG in military recruits and to provide scientific evidence for further prevention of RSV infection.Methods A seroepidemiological study was conducted using an enzyme-linked immunosorbent assay（ELISA）.Serum samples from 364 recruits from 16 provinces from 2001 to 2008 were tested for RSV antibody IgG and the overall positive rate was analyzed statistically.Results Of serum samples from the 364 recruits,57 were positive for RSV antibody IgG at a rate of 15.66%.From 2001 to 2008,the positive rate ranged from 6.52 % to 28.89%;differences in that rate each year were statistically significant（χ2=21.006,P〈0.05）.Recruits came from 16 provinces and cities;the level of RSV antibody IgG was higher in recruits from Tianjin（47.83%）,Guangxi（39.13%）,Shandong（34.78%）,and Gansu（21.74%） but lower in recruits from other provinces and cities;the difference in IgG levels was statistically significant（χ2=72.323,P〈0.05）.There was no significant correlation between positivity for antibody IgG and the recruits’ prior occupation.Conclusion Military recruits had relatively low levels of RSV antibody IgG,and there were significant regional and annual differences in RSV infection,warranting closer scrutiny.
出处
《中国病原生物学杂志》
CSCD
北大核心
2012年第8期612-614,共3页
Journal of Pathogen Biology
基金
全军医学科学技术研究"十二五"课题(No.CWS11L200)
关键词
入伍新兵
呼吸道合胞病毒
抗体
流行病学调查
Military recruit； respiratory syncytial virus（RSV）； antibody level； epidemiological study
