摘要
目的探讨抑郁症患者血清瘦素(Lep)、胰岛素(Ins)水平的变化。方法采用放射免疫法测定35例抑郁症患者应用帕罗西汀20 mg/d治疗前1 d、治疗4周末和30例健康对照者的血清LepI、ns水平,以HAMD-24评定患者的严重程度。结果对照者血清与患者血清Lep性别差异有统计学意义,Lep水平均与体质指数有关(P<0.01)。有体重减轻的抑郁症患者与无体重减轻的抑郁症患者比较血清Lep降低,差异有统计学意义(P<0.05),有家族史的抑郁症患者Ins高于无家族史的抑郁症患者,差异有统计学意义(P<0.05)。帕罗西汀治疗后女性Lep水平升高,差异有统计学意义(P<0.05)。结论有体重减轻的抑郁症患者血清Lep降低,提示Lep在抑郁症或抑郁症某些亚型的发病机制中可能起一定作用,但仍需进一步的研究证实,帕罗西汀可能对Lep的影响存在性别差异,遗传因素可能在抑郁症伴发糖尿病的发病机制中起着一定的作用。
Objective To investigate the changes of serum leptin （Lep） and insulin （Ins） in patients with depressive disorder. Methods The serum Lep and Ins, and HAMD - 24 score were determined in 35 patients with depres- sive disorder and in 30 healthy controls 1 day before treatment and at 4th weekend. Results Significantly lower Lep was revealed in male patients, also in those with weight loss. The serum Ins was significantly higher in depressive patients with a positive family history. Furthermore, significant elevation of serum Lep was observed in female patients after treatment with paroxetine. Conclusion Lep is suggested to play an important role in depressive disorder, which required further re- search. Paroxetine probably increases serum Lep in female patients with depressive disorder. It is also suggested that heredity factors play roles in depression complicated with diabetes mellitus.
出处
《广东医学》
CAS
CSCD
北大核心
2012年第17期2568-2571,共4页
Guangdong Medical Journal
关键词
抑郁症
瘦素
胰岛素
depression
leptin
insulin
