期刊文献+

替米沙坦联合胰激肽原酶治疗早期糖尿病肾病疗效观察

下载PDF
导出
摘要 目的:观察替米沙坦联合胰激肽原酶治疗早期糖尿病肾病疗效,探讨替米沙坦联合胰激肽原酶治疗早期糖尿病肾病的临床效果。方法:选取早期糖尿病肾病患者46例,分为对照组和治疗组各23例,对照组在基础治疗基础上,予以替米沙坦,治疗组在替米沙坦的基础上加用胰激肽原酶治疗,观察两组在尿蛋白各项(MA1b、TRF、β-MG、α-MG、IgG),总胆固醇(TG)、三酰甘油(TC)、糖化血红蛋白(HbA1C)、SCr、BUN的各项指标。结果:治疗后两组尿微量白蛋白(UAER)各项均较治疗前降低(P<0.05),治疗组比对照组降低更明显(P<0.01)。与对照组比较,治疗组UAER也有显著下降(P<0.01)。与对照组相比,治疗组能明显降低TG、TC(P<0.01)。结论:使用替米沙坦联合胰激肽原酶治疗早期糖尿病肾病疗效显著。
出处 《吉林医学》 CAS 2012年第26期5663-5664,共2页 Jilin Medical Journal
  • 相关文献

参考文献3

二级参考文献19

  • 1Robins SJ. Fibrates and conmnaryheart disease reduction in diabetes[ J]. Curt Opin Endocrinol Diabetes,2002,9:312 - 322.
  • 2Cusi K. Cardiovascular risk management in type 2 diabetes:from clinical trials toclinical practice [ J ]. Endocrinologist,2001,11:474 -490.
  • 3UK Prospective Diabetes Study (UKP-DS) Group. Intensive blood - glucosecontrol with sulphonylureas or insulin compared with conventional treatmentand risk complications in patients with type 2 diabetes( UKPDS 33 ) [ J]. Lancet, 1998, 352:837 - 853.
  • 4Vlassara H. Recent progress in advanced glycation end products and diabetic complications [ J ]. Diabetes, 1997,46[ Supp1]2:S19 -25.
  • 5Lyons TJ, Jenkins AJ. Glycation, oxidation and lipoxidation in the develovment of the complications of diabetes mellitus : a" carbonyl stress" hypothesis [ J ].Diabete Rev, 1997,5:365 - 391.
  • 6Turner RC, Millns H, Nell HAW, et al.Risk factors for coronary artery diseasenon - insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study[ Jl. Br Med J, 1998,316 : 823- 828.
  • 7Turner BC. The U. K. prospective diabetes study:a review[J]. Diabetes Care,1998, 21 [ suppl ] 3:35 -38.
  • 8Klein R, Klein BEK. Relation of glycenile control to diabetic complications anhealth outcomes. Diabetes Care,1998,21[ Suppl] 3:39 -43.
  • 9UK Prospective Diabetes Study Group.Tight blood pressure control and risk ofmacrovascular and microvascular complications in type 2 diabetes: UKPDS 38[J]. BMJ, 1998,317:703-713.
  • 10American Diabetes Association. Treatment of hypertension in adults with diabetes[J]. Diabetes Care,2002,25:199 -201.

共引文献170

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部