摘要
建立了关于卡巴拉汀贴片的含量的高效液相色谱(HPLC)测定方法,采用离体的豚鼠皮肤作为透皮屏障,运用改进的Franz扩散池,观察卡巴拉汀透皮贴剂的体外透皮效果。结果显示,在9.69￣116.32μg/mL的浓度范围中卡巴拉汀的线性关系良好,精密度RSD是0.12%￣0.47%,检测限值是0.17pg/mL,低浓度的平均回收率为98.79%、中浓度为98.59%、高浓度为99.88%。实验中建立的HPLC方法具有准确、灵敏和操作简便的优点,对卡巴拉汀贴含量测定效果好。
set up about the content of the statins karbala patch high performance liquid chromatography （HPLC） method.using the improved Franz diffusion cell was observed in Kabbala,transdermal fentanyl transdermal effect. The results showed, in the concentration range of 9.69- 1 16.32u g/mL Kabbala ting good linearity, precision of RSD is 0.12% - 0.47%, limit of detection is0.17 pg/mL, low concentrations of the average recovery rate was 98.79%,in concentrations of 98.59%, high concentration of 99.88%. The proposed HPLC method is accurate,sensitive and the advantages of simple operation, the Kabbala Ting paste determination effect is good.
出处
《求医问药（下半月刊）》
2012年第7期403-404,共2页
Seek Medical and Ask The Medicine
关键词
HPLC
透皮贴剂
卡巴拉汀
HPLC
Transdermal patches
Karbala statins.
