摘要
目的 动态观察肝移植术后早期肝能量代谢变化与供肝存活能力的关系。方法 用猕猴制作同种异体原位肝移植模型 ,采用动脉血酮体比率 (arterialbloodketonebodyratio ,AKBR)作主要监测手段 ,对受体移植术前、术中及术后早期动态观察。结果 根据受体术后存活时间大于或小于 2 4小时分为A、B两组 ,A组 (n=5 )受体存活 2 9～ 16 8小时 ,B组 (n=9)受体存活 5～ 2 2小时。受体全肝血流阻断进入“无肝期”后 ,所有受体AKBR迅速下降至极低水平 ,与阻断前比较 ,其差异有高度显著性意义 (P <0 .0 1)。A组移植后 12小时内 ,AKBR迅速恢复并持续稳定在 0 .7以上 ;B组移植后早期 (30分钟内 )AKBR一度上升但又迅速下降 ,12小时时降至 0 .4以下。
Objective To study the relation between changes of the hepatic energy metabolism and allograft viability in early phase after orthotopic liver transplantation, arterial blood ketone body ratio (AKBR) was measured in pre intra and post operative phase. [WT5”HZ]Methods [WT5”BZ]The monkeys were divided into two groups in accordance with survived times. A group (>24h), 5 monkeys survived 29[HT6,7”]—168 postoperative hours; B group (<24h), 9 monkeys survived only 5[HT6,7”]—22 hours. [WT5”HZ]Results [WT5”BZ]AKBR in all models immediately decreased to extraordinarily low state in anhepatic phase (versus preanhepatic phase, P <0.01), and A group recovered rapidly to the normal levels, and maintained continuously for 12 postoperative hours above the level of 0.7. In contrast in B group, AKBR decreased below 0.7 rapidly and failed to restore to the normal level. Within 12 hours postoperatively, in B group, AKBR was lower than 0.4. [WT5”HZ]Conclusion [WT5”BZ]AKBR is a sensitve indicator to the allograft viability in the early phase after hepatic transplantation.
出处
《中国普外基础与临床杂志》
CAS
2000年第4期211-213,共3页
Chinese Journal of Bases and Clinics In General Surgery
关键词
肝移植
供肝活力
手术后
肝能量代谢
Liver transplantation
Early phase after transplantation
Allograft viability
Arterial ketone body ration
