摘要
目的:研究生脉与磷酸肌酸钠联合应用对心力衰竭大鼠的保护作用。方法:采用结扎大鼠左冠状动脉制备心力衰竭大鼠模型。将术后48h存活的大鼠分为伪手术组、模型组、生脉注射液组、磷酸肌酸钠组、生脉+磷酸肌酸钠组,给药6周。6周后进行血流动力学检查,测定血液中丙二醛(MDA)含量及超氧化物岐化物(SOD)活性,并计算心脏重量指数(HW/BW)和左心室重量指数(LVW/BW)。结果:生脉+磷酸肌酸钠能显著降低心力衰竭大鼠的心率和左室舒张末压力,升高血压、左室收缩压等,显著降低血清中MDA含量,提高血清SOD活性。此外,能降低心脏的HW/BW和LVW/BW。以上指标与模型组相比均有显著性差异。生脉+磷酸肌酸联用对上述指标的改善均明显优于单纯应用生脉注射液或磷酸肌酸钠(P<0.05)。结论:生脉与磷酸肌酸钠联合应用对心力衰竭大鼠具有明显保护作用,其效果明显优于单一用药,提示两药有良好的协同作用。
Objective：To study the protective effect of combined use of Shengmai （SM） and creatine phosphate sodium （CPs） on heart failure of rats. Methods： Heart failure was caused by ligating the left anterior descending coronary artery. The rats were randomly divided into sham, model, SM treated groups, CPs treated groups, SM ＋ CPs treated groups. The drug or vehicle was given by peritoneal injection for 6 weeks after operation. Then the hemodynamic parameters were detected, contents of MDA and SOD were measured, and the HW/BW and LVW/BW were counted. Results： Compared with model group, SM ＋ CPs was found to decrease in HR and LVEDP and increase in SBP, DBP, LVSP and ± LVdp/dt （P〈O. 05）. Furthermore, SM ＋ CPs increased in MDA and decreased in SOD significant ly compared with the model （P〈0.05）. Additionally, SM ＋ CPs decreased significantly in HW/BW and LVW/BW of rats （P〈0.05）. Conclusion：Compared with the mono-therapy, combined use of Sheng mai and creatine phosphate sodium protects more effectively the rats from heart failure.
出处
《国际心血管病杂志》
2012年第5期309-311,共3页
International Journal of Cardiovascular Disease
关键词
生脉
磷酸肌酸钠
心力衰竭
Shengmai
Creatine phosphate sodium
Heart failure
