摘要
动脉粥样硬化是血管慢性增殖性炎症过程,也是对血管损伤的反应和修复过程。高迁移率蛋白1作为一种重要的晚期炎症介质,参与多种炎性疾病的发生发展。Toll样受体是最重要的先天免疫系统的模式识别受体识别微生物的病原相关分子模式。高迁移率蛋白1可能通过Toll样受体激活炎性反应,参与动脉粥样硬化的发生和发展。
Atheroselerosis is a vascular chronic inflammatory hyperplastic process, and is also the reaction to blood vessel damage and the healing process. As an important late inflammatory mediator, high mobility group box 1 （ HMGB1 ） is involved in the occurrence and development of various inflammatory diseases. Toll-like receptors （ TLRs ） are the most important pattern-recognition receptors of the innate immune system that recognize pathogen-associated molecular patterns （ PAMPs ） of microbes. HMGB1 may activate the inflammatory reaction through Toll-like receptors, and thereby participate in occurrence and development of atherosclerosis.
出处
《心血管病学进展》
CAS
2012年第5期667-669,共3页
Advances in Cardiovascular Diseases
基金
四川省省教育厅合作项目
项目编号2006J13-72
