摘要
小口径血管在临床上有很大需求,但小口径血管再狭窄率很高。体内组织工程是改善小口径血管功能、实现血管再生的有效手段。介绍了小口径人工血管的国内外研究发展动态,详述了作者实验室在构建小口径人工血管方面的设计思路和研究所取得的主要进展。研究包括支架材料结构设计与制备技术,支架材料表面功能化修饰,内皮祖细胞捕捉,血管平滑肌再生,抗凝血和促内皮细胞黏附,血管再生微环境的构建等。最后对小口径人工血管研究尚需解决的科学问题和研究方向进行了讨论。
Although there is a growing demand of small-diameter vascular grafts for cardiovascular disease, the inci- dence rate of restenosis caused by vascular grafts remains high. An effective approach to improve the function of small-di- ameter vascular grafts and realize the blood vessel regeneration would be to induce a healing response in vivo for tissue en- gineering. In this article, we summarize the recent research developments on small-diameter vascular grafts, and highlight the main designing ideas and research outcomes in our laboratory. The work includes structural design and fabrication of porous scaffolds, anti-clotting modification, functionalization for endothelial progenitor cells （EPCs） capture, creation of micro-environment for vascular smooth muscle regeneration and angiogenesis. Some directions and problems on future re- search in these areas are also discussed.
出处
《中国材料进展》
CAS
CSCD
2012年第9期6-19,50,共14页
Materials China
基金
国家973研究计划项目(2011CB964903
2012CB725203)
国家自然科学基金资助项目(50830104
51073081
81000680)
关键词
人工血管
组织工程
支架制备
干细胞捕捉
内皮化
平滑肌再生
细胞外微环境
vascular grafts
tissue engineering
scaffold preparation
stem cell capture
endothelialization
smoothmuscle regeneration
extracelluiar microenvironments
