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模式生物斑马鱼在多囊肾病发病机制及治疗中的应用进展

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摘要 审阅多囊肾病（polycystic kidney disease,PKD）是以多个肾小管衬里上皮细胞形成、液体充满囊泡为特征的紊乱性疾病,囊肿多发于肾小管和集合管,上皮细胞过度增殖是PKD的致病原因也是主要发育缺陷.常染色体显性遗传性多囊肾病（ADPKD）是其中最为常见的人类单基因遗传性病变,人群发病率1/400~1/1 000,全世界大约有一千二百五十万患者,中国大约有一百五十万多囊肾患者.
作者 王文苓 梅长林
机构地区 第二军医大学附属长征医院肾内科
出处 《中国中西医结合肾病杂志》 2012年第9期833-835,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
关键词 常染色体显性遗传性多囊肾病 发病机制 模式生物 斑马鱼 应用 治疗 细胞过度增殖 衬里上皮
分类号 R692.1 [医药卫生—泌尿科学]
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参考文献10

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二级参考文献14

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共引文献5

中国中西医结合肾病杂志
2012年 第9期

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