1Baker DE.Application of chmnotherapy to the treatment of cancer:can changing the timing of drug administration influence efficacy and toxicity[J].Advances in Pharmacy,2004,2(3):222-228.
3[3]Lévi F. Circadian Chronotherapy for Human Cancers [J].Lancet Oncol, 2001, 2(5): 307～315
4[4]Lévi F. Chronopharmacology of anticancer agents. In: Redfern PH, Lemmer B, eds. Physiology and pharmacology of biological rhythm[M]. Berlin: Springer-Verlag. 1997, 299～311
5[5]Granda TG, Lévi F. Tumor Based Rhythms of Anticancer Efficacy in Experimenral Models[J]. Chronobiol Int, 2002, 19(1):21～41
6[6]Granda TG, Filipski E, D'Attino RM, et al. Experimental Chronotherapy of Mouse Mammary Adenocarcinoma MA13/C with docetaxel and Doxorubicine as Single Agent and in Combination[J]. Cancer Res, 2001, 61(5): 1996～2001
7[7]Smaaland R, Sothern R B, Laerum O D, et al. Rhythm in Human Bone Marrow and Blood Cells [J]. Chronobiol Int,2002, 19(1): 101～127
8[8]Bjarnason GA, Jodan R. Rhythm in Human gastrointestinal Mucosa and Skin[J]. Chronobiol Int, 2002, 19(1): 129～140
9[9]Harris BE, Song R, Soong SJ, et al. Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil level: evidence for circadian variation of plasma drug level in cancer patients receiving 5-fluorouracil by protracted continuous infusion[J]. Cancer Res, 1990, 50(1): 197～201
10[10]Petit E, Milano G, Lévi F, et al. Circadian Varying Plasma Concentration of 5-Fluorouracil During 5-Day Continuous Venous Infusion at Constant Rate in Cancer Patients[J]. Cancer Res, 1988, 48(6): 1676～1679
