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普瑞巴林联合曲马多治疗急性带状疱疹疼痛的临床观察 被引量：3

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摘要 目的观察普瑞巴林联合曲马多治疗中重度急性带状疱疹疼痛的临床疗效和安全性。方法急性带状疱疹患者45例,随机分为3组,各15例。T组:曲马多缓释片初始剂量100 mg,q12 h,po;P组:普瑞巴林胶囊初始剂量75mg,bid,po;TP组:曲马多缓释片初始剂量50 mg,q12 h,po,普瑞巴林胶囊剂量75 mg,bid,po。根据疼痛程度变化调整药物剂量,疗程4周。随访疼痛评分(NRS)、睡眠质量评分和曲马多使用量,并行综合评估。结果 3组患者治疗后NRS评分均显著降低,TP组的NRS评分下降更为显著;睡眠质量明显改善;TP组和T组患者疼痛缓解显效率高于P组。TP组曲马多使用量低于T组。结论普瑞巴林和曲马多镇痛可能存在协同作用,两者联合治疗急性带状疱疹疼痛具有多模式镇痛的优点。
作者 于卫 黄觉升 林根 马薇涛 李红英
机构地区 广东省人民医院(广东省医学科学院)麻醉科
出处 《医药导报》 CAS 北大核心 2012年第9期1147-1149,共3页 Herald of Medicine
关键词 普瑞巴林 曲马多 带状疱疹 疼痛
分类号 R971.2 [医药卫生—药品] R752.12 [医药卫生—皮肤病学与性病学]
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参考文献8

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二级参考文献16

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共引文献20

同被引文献41

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二级引证文献7

医药导报
2012年 第9期

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