摘要
目的 探讨不同类型恶性肿瘤患者血清水平变化同型半胱氨酸（Hcy）及胱抑素C（CysC）水平变化。方法 120例恶性肿瘤患者按照疾病类型分成A组（胃癌）、B组（食管癌）、C组（肝癌）和D组（鼻咽癌）,以25例健康志愿者为对照组。采用酶联免疫（ELISA）法检测四组患者血清Hcy及CysC水平。结果 A组、B组、C组和D组恶性肿瘤患者血清Hcy浓度分别为（19.71±3.40）μmol/L、（23.27±9.57）μmol/L、（21.37±0.38）μmol/L和（16.27±1.24）μmol/L,均显著高于对照组（均P〈0.05）;A组、B组、C组和D组恶性肿瘤患者血清中CysC浓度分别为（19.71±3.40）mg/L、（19.71±3.40）mg/L、（19.71±3.40）mg/L和（19.71±3.40）mg/L,均显著高于对照组（均P〈0.05）。胃癌血清Hcy及CysC水平与癌胚抗原（CEA）水平具有正相关性（r=0.9643、0.9842）,食管癌、肝癌和鼻咽癌患者血清Hcy及CysC水平与胃癌患者血清CEA水平无相关性。结论 血清Hcy及CysC检测在恶性肿瘤诊断上具有潜在的临床价值。
Objective To investigate the expression of homocysteine and cystatin C in the serum of patients with different types of malignant tumors.Methods 120 patients with malignant tumors were divided into group A（gastric cancer）,group B（esophageal canler）,group C（liver cancer） and group D（nasopharyngeal carcinoma） according to the type of disease,25 healthy volunteers were selected as control group.Enzyme-linked immunosorbent（ELISA） was used to measure serum homocysteine and cystatin C levels in four groups of patients.Results Homocysteine level of group A,group B,group C and group D were （19.71±3.40）μmol/L,（23.27±9.57）μmol/L,（21.37±0.38）μmol/L and （16.27±1.24）μmol/L,which were significantly higher than those of the control group （all P〈0.05）.Cystatin C levels of group A,group B,group C and group D were （19.71±3.40）mg/L,（19.71±3.40）mg/L,（19.71±3.40）mg/L and （19.71±3.40）mg/L,which were significantly higher than those of the control group （all P〈0.05）.Serum homocysteine and cystatin C levels of gastric cancer positively correlated with carcinoembryonic antigen（CEA） level（r=0.9643,0.9842）.However,serum homocysteine and cystatin C levels of esophageal cancer,liver cancer and nasopharyngeal carcinoma had no correlation with serumCEA level.Conclusion Cystatine C and homoeysteine have potential clinical value on the diagnosis of malignant tumors.
出处
《中国基层医药》
CAS
2012年第21期3208-3209,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
癌
半胱氨酸
抑素类
癌胚抗原
酶联免疫吸附测定
Carcinoma
Cystatine
Chalones
Carcinoembryonic antigen
Enzyme-linked immunosorbent assay
