期刊文献+

地屈孕酮联合孕康口服液治疗早期先兆流产34例疗效观察 被引量:19

Observation on the Therapeutic Effects of Dydrogesterone Combined with Yunkang Oral Liquid in Treatment of 34 Cases of Early Threatened Abortion
下载PDF
导出
摘要 目的探讨地屈孕酮联合孕康口服液治疗早期先兆流产的疗效。方法将早期先兆流产患者68例随机分为两组,各34例,治疗组以地屈孕酮片联合孕康口服液治疗;对照组以黄体酮注射液治疗。两组均用药至症状消失后7 d。观察比较两组的临床疗效。结果治疗组总有效率高于对照组,差异有统计学意义(94.12%vs 76.47%,P<0.05)。结论地屈孕酮联合孕康口服液治疗早期先兆流产疗效优于黄体酮肌内注射,服用方便,可减少长期肌内注射的痛苦,值得临床推广应用。 Objective To explore the clinical effect of dydrogesterone combined with Yunkang oral liq- uid in treating early threatened abortion. Methods 68 patients with early threatened abortion were randomly divided into two groups,34 cases in each group. Treatment group was given dydrogesterone combined with yunkang oral liquid. Control group was given progesterone injection. Both groups were treated until 7 days af- ter disappearance of symptoms. The efficacy of the two groups were observed. Results The total efficay of treatment group was higher than that of the control group ( 94, 12% vs76.47% , P 〈 0.05 ). Conclusion Dydrogesterone combined with yunkang ora/liquid effectin the treatment of ear/y threatened abortion is better than intramuscular progesterone. It can reduce the pain of long-term intramuscular injection because of its convenient administration mode, thus is worthy of clinical aoolieation.
出处 《医学综述》 2012年第19期3335-3336,共2页 Medical Recapitulate
关键词 地屈孕酮 孕康口服液 先兆流产 临床疗效 Dydrogesterone Yunkang oral liquid Threatened abortion Clinical effect
  • 相关文献

参考文献5

  • 1Chakravarty BN,Shirazze HH,Dam P,et al.Oral dydrogesteroneversus intravaginal micronised progesterone as luteal phase supportin assisted reproductive technology(ART)cycles:results of a ran-domised study[J].J Steroid Biochem Mol Biol,2005,97(5):416-420.
  • 2Omar MH,Mashita MK,Lim PS,et al.Dydrogesterone in threateneda-bortion:pregnancy outcome[J].J Steroid Biochem Mol Biol,2005,97(5):421-425.
  • 3李雪梅,赵坤,刘庆芝,李晓英,欧秀华,唐雪莲.地屈孕酮治疗先兆流产的临床观察[J].实用医学杂志,2007,23(8):1245-1246. 被引量:35
  • 4Joachim R,Zenclussen AC,Polgar B,et al.The progesterone deriva-tive dydrogesterone abrogates murine stress-triggered abortion by in-ducing a Th2 biased local immune response[J].Steriods,2003,68(10/13):931-940.
  • 5俞谨.实用中西医结合妇产科学[M].北京:中国科学技术出版社,1996:90.

二级参考文献8

  • 1Gruber C J,Huber J C.The role of dydrogesterone in recurrent(habitual) abortion[J].J Steriod Biochem Mol Biol,2005,97(5):426-430.
  • 2Szekeres-Bartho J,Kilar F,Falkay G,et al.The mechanism of the inhibitory effect of progesterone on lymphocyte cytotoxicity:Ⅰ.Progesterone-treated lymphocytes release a substance inhibiting cytotoxicity and prostaglandin synthesis[J].Am J Reprod Immunol Microbiol,1985,9(1):15-18.
  • 3Szeleres-Bartho J,Barakonyi A,Par G,et al.Progesterone as an immunomodulatory molecule[J].Int Immunopharmacol,2001,1 (6):1037-1048.
  • 4Kelemen K,Bognar I,Paal M,et al.A progesterone-induced protein increases the synthesis of asymmetric antibodies[J].Cell Immunol,1996,167(1):129-134.
  • 5Joachim R,Zenclussen A C,Polgar B,et al.The progesterone derivative dydrogesterone abrogates murine stress-triggered abortion by inducing a Th2 biased local immune response[J].Steriods,2003,68 (10-13):931-940.
  • 6Critchley H O,Jones R L,Lea R G,et al.Role of inflammatory mediators in human endometrium during progesterone withdrawal and early pregnancy[J].J Clin Endocrinol Metab,1999,84(1):240-248.
  • 7Goldstein P,Berrier J,Rosen S,et al.A meta-analysis of randomized control trials of progestational agents in pregnancy[J].Br J Obstet Gynecol,1989,96(3):265-274.
  • 8Omar M H,Mashita M K,Lim P S,et al.Dydrogesterone in threatened abortion:pregnancy outcome[J].J Steriod Biochem Mol Biol,2005,97(5):421-425.

共引文献37

同被引文献113

  • 1侯敬凤,吴红波,董桂霞,吴修华.孕康口服液治疗先兆流产疗效观察[J].中国中医基础医学杂志,2005,11(8):638-638. 被引量:4
  • 2李雪梅,赵坤,刘庆芝,李晓英,欧秀华,唐雪莲.地屈孕酮治疗先兆流产的临床观察[J].实用医学杂志,2007,23(8):1245-1246. 被引量:35
  • 3曹泽毅主编.中华妇产科学.第2版北京:人民卫生出版社,2004,660 - 663.
  • 4Kelemen K, Bognar I, Pa A, et al. A progresterone induced protein in- creases the synthesis of asymmetric antibodies [ J ]. Cell Immunol, 2006,167(1 ) :129 - 134.
  • 5Wang HI,Yang MJ, Chang CM, et al. Oxytocin antagonist successfully prevents from threatened abortion in 15 weeks' gestation [ J ]. Taiwan J Obstet Gynecol,2011,50 (2) :220 - 222.
  • 6谢幸,苟文丽.妇产科学.第8版.北京:人民卫生出版社,2005:113.
  • 7黄金芳,王艳.地屈孕酮与黄体酮治疗先兆流产.药物与临床,2011,6(18):18.
  • 8吴娜.地屈孕酮联合HCG治疗复发性流产临床研究[J].中国药物经济学,2014,7(3):225-226.
  • 9陈春艳.地屈孕酮用于治疗早期先兆流产的临床疗效观察[J].中国医药导刊,2012;14(2):607-608.
  • 10伍玉凤.地屈孕酮与黄体酮治疗先兆流产疗效观察[J].中外健康文摘,2014,22(13):142-243.

引证文献19

二级引证文献142

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部