摘要
目的:观察不同剂量前列地尔注射液干预早期糖尿病肾病(DN)的临床疗效。方法:临床确诊为早期DN患者90例随机入选常规剂量前列地尔注射液(10μg qd)组(A组)与大剂量前列地尔注射液(20μg qd)组(B组),分别为44例和46例,疗程均为8周,观察2组治疗前后血尿素氮(BUN)、血肌酐(Scr)、尿白蛋白排泄率(UAER)、尿β2-微球蛋白(Uβ2-MG)、尿α1微球蛋白(Uα1-MG)的变化。结果 :治疗后2组BUN、Scr、UAER、Uβ2-MG、Uα1-MG水平均显著下降(P<0.05,P<0.01),且B组下降更明显(P<0.05)。结论:早期大剂量前列地尔注射液能更有效地减少早期糖尿病患者的尿蛋白排出量、减轻肾脏损伤、改善肾功能,且呈剂量依赖性。
Objective：To observe the curative effect of treatment with varied dosage prostaglandin E1 （PGEl） injection for early diabetic nephropathy.Methods：Ninety cases with early diabetic nephropathy were randomized divided into 2 groups,of which PGE1 injection 10μg qd（n=44）and PGE1 injection 20μg qd（n=46）.The course of treatment lasted for 8 weeks.Examine the level of serum creatinine （Scr）,blood urea nitrogen（BUN）,urinary albumin excretionrate（UAER）,urinary 152-microglobulin（U^2-MG）,urinary cq-microglobulin（U^l-MG）before and after therapy.Results：The level of Scr,BUN, UAER,UI32-MG, Uctl-MG of both groups were all decreased after therapy （P〈O.O5,P〈0.01）.PGE1 injection 20p.g qd was superior to PGE1 injection 10p, g qd.Conclusion：Earlier period large dosage PGEI can decrease urine protein,protect the kidney from injury,improve function of kid- ney,and the curative effect is correlated with the dosage.
出处
《中日友好医院学报》
2012年第5期284-286,共3页
Journal of China-Japan Friendship Hospital
