摘要
目的:探讨急性脑外伤患者血浆C-反应蛋白(CRP)浓度与CT表现的关系。方法:收集急性脑外伤患者和健康体检正常者各86例,采用ELISA测定血浆CRP浓度,统计并分析急性脑外伤患者血浆CRP浓度的变化及与CT表现的关系。结果:脑外伤患者血浆CRP浓度(6.87±3.94)mg/L较健康体检正常者(1.33±0.74)mg/L显著升高(P<0.01)。环池受压、中线移位(>5mm)或蛛网膜下腔出血患者血浆CRP浓度均显著高于非环池受压、非中线移位或非蛛网膜下腔出血患者(均P<0.05)。结论:急性脑外伤患者血浆CRP浓度与环池受压、中线移位(>5mm)和蛛网膜下腔出血显著相关,可作为一项生物标志物用于反映急性脑外伤严重程度。
Objective This study aimed to investigate the correlations between computed tomographic manifestations and plasma C-reactive protein concentration in acute traumatic brain injury.Methods Plasma C-reactive protein concentrations in eighty-six patients with acute traumatic brain injury and 86 healthy controls were measured using ELISA.The change of plasma C-reactive protein level and its correlation with computed tomographic manifestations were analyzed statistically.Results Plasma C-reactive protein level was significantly higher in patients with acute traumatic brain injury than in healthy controls（6.87±3.94 mg/L vs 1.33±0.74 mg/L;P5mm） or subarachnoid hemorrhage than without that（all P5mm） and subarachnoid hemorrhage,and thus can be identified as a biomarker mirrors the severity of acute traumatic brain injury.
出处
《放射免疫学杂志》
CAS
2012年第5期562-564,共3页
Journal of Radioimmanology
关键词
急性脑外伤
CT
C-反应蛋白
acute traumatic brain injury
computerized tomography（CT）
C-reactive protein（CRP）
