摘要
目的:揭示慢性荨麻疹患者血浆肿瘤坏死因子-α(TNF-α)浓度的变化,分析其对慢性荨麻疹的诊断价值。方法:选取门诊治疗的慢性荨麻疹患者及健康体检者各86例,ELISA检测血浆TNF-α浓度,对数据进行统计分析。结果:慢性荨麻疹患者血浆TNF-α浓度(4.2±1.8)ng/ml显著高于对照组(1.8±0.7)ng/ml(P<0.001),与临床评价总积分(r=0.471,P<0.01)和病程(r=0.424,P<0.01)呈显著正相关。多因素分析显示,血浆TNF-α浓度(OR=1.738,95%CI=1.117～4.924,P<0.05)是慢性荨麻疹发病的独立危险因素。ROC曲线辨别了血浆TNF-α浓度的曲线下面积(曲线下面积=0.842,95%CI=0.775～0.913,P<0.001)和判定界值(>2.8 ng/ml),对诊断慢性荨麻疹有较高的灵敏度(83.7%)和特异度(79.1%)。结论:TNF-α可能参与慢性荨麻疹的发病机制,其浓度可有效诊断慢性荨麻疹。
Objective To investigate the changes of plasma necrosis factor-α concentration in patients with chronic urticaria and analyze its diagnostic value.Methods 86 patients with chronic urticaria and 86 healthy controls were enrolled in this study.Determining plasma tumor necrosis factor-α（TNF-α） concentration with ELISA.Statistical analysis was taken.Results Plasma TNF-α concentration was significantly higher in patients than those of healthy controls（4.2±1.8 ng/ml vs 1.8±0.7）ng/ml,P2.8 ng/ml） that dignosed chronic urticaria with high sensitivity（83.7%） and specificity（79.1%） respectively.Conclusion TNF-α may be involved in pathogenesis of chronic urticaria,and its concentration can effectively in diagnosis of chronic urticaria.
出处
《放射免疫学杂志》
CAS
2012年第5期567-569,共3页
Journal of Radioimmanology
关键词
慢性荨麻疹
肿瘤坏死因子-Α
发病机制
诊断
chronic urticaria
tumor necrosis factor-α（TNF-α）
pathogenesis
diagnosis
