摘要
目的观察比索洛尔对老年高血压慢性心力衰竭(心衰)患者左心室重构的影响。方法选择老年高血压舒张功能不全患者98例,随机分为干预组(口服比索洛尔1.25～10 mg/d)53例和对照组45例,随访6个月。采用常规超声心动图和Tei指数检查,并进行比较分析。结果干预组治疗后左心室舒张末内径、室间隔厚度、左心室后壁厚度较治疗前明显降低(P<0.05),且优于对照组(P<0.05);干预组治疗后左心室等容松弛减慢指标、左心室早期充盈减慢指标优于治疗前(P<0.01),并优于对照组(P<0.05);干预组左心室Tei指数较治疗前显著改变(P<0.01),且优于对照组(P<0.05)。结论比索洛尔对老年高血压慢性心衰及心室重构有明显疗效、安全性好。Tei指数对综合评价心脏整体功能比常规超声心动图可能更敏感、更加合理。
Objective To observe the effect of bisoprolol on chronic heart failure and left ventricule remodeling in elderly hypertensive patients. Methods Ninety-eight elderly hypertensive patients with diastolic insufficiency were randomly divided into bisoprolol treatment group（n = 53） and control group（n= 45） and received conventional antl-hypertension treatment and congestive heart failure treatment,respectively. Patients in bisoprolol treatment group were given oral bisoprolol （1.25-10 mg/d） for 6 months. Then,improvement in their diastolic function of left ventricule was compared according to their ultrasoundcardiogram and Tel index before and after treatment. Results The improvement of inner diameter of left ventricule at the end-diastolic phase,interven- tricular septal thickness, posterior wall thickness of left ventricule was significantly better in biso- prolol group than in control group after treatment（P^0.05）. The isovolumic relaxation index, early filling relaxation index, and Tei index of left ventricule were significantly better in bisoprolol group than in control group（P〈0.05） and after treatment than before treatment（P〈0.01）. Conclusion Bisoprolol exerts its significant effects on chronic heart failure and left ventricule remod- eling in elderly hypertensive patients with a good safety. The Tei index is more sensitive and rea- sonable than conventional ultrasoundcardiogram for the assessment of heart function.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2012年第10期1054-1056,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
