摘要
目的研究盐酸度洛西汀胶囊(抗抑郁药)在健康人体内的药代动力学。方法 10名健康受试者,男女各半,单剂量口服盐酸度洛西汀肠溶胶囊60 mg。用高效液相色谱法测定血浆中度洛西汀的浓度;用DAS 2.0计算药代动力学参数。结果度洛西汀的主要药代动力学参数:Cmax为(58.74±7.25)μg.L-1,Tmax为(6.10±0.74)h,t1/2(ke)为(15.79±1.17)h,AUC0-72为(1423.01±157.29)μg.h.L-1。结论度洛西汀在健康人体内符合一级吸收的一室模型。
Objective To study the pharmacokinetics of duloxetine hydroehloride enteric capsules in healthy volunteers.Methods Ten healthy volunteers（five males and five females） received 60 mg duloxetine hydroehloride enteric capsules at a single oral dose.The concentrations of duloxetine in plasma were determined by HPLC.The pharmacokinetic parameters were calculated by DAS program.Results After a single dose of 60 mg duloxetine hydroehloride enteric capsules,the pharmacokinetic parameters for duloxetine were as follows： Cmax was（58.74±7.25） μg·L-1,Tmax was（6.10±0.74）h,t1/2（ke） was（15.79±1.17） h,AUC0-72 was（1423.01±157.29） μg·h·L-1.Conclusion Duloxetine was fitted to a one-compartment model with first absorption.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2012年第9期656-658,共3页
The Chinese Journal of Clinical Pharmacology
