摘要
目的 :探讨弥漫性轴突损伤 ( diffuse axonal injury,DAI)患者血清神经元特异性烯醇化酶 ( neuron specificenolase,NSE)浓度的变化及临床意义。 方法 :选择符合 DAI诊断标准的脑外伤患者 13例 ,均行 CT扫描。于入院时或损伤后 12 h左右采血检测血清中 NSE浓度。 结果 :13例 DAI患者中 ,CT扫描显示颅内有组织撕裂出血改变者 7例 ,脑肿胀者 3例 ,阴性者 3例。 DAI患者血清 NSE值较正常对照组明显升高 ,分别为 ( 46 .5 3± 2 4.2 5 )μg/ L和 ( 6 .96± 2 .5 2 )μg/ L。在死亡或植物生存患者 NSE值升高更明显。 结论 :DAI患者血清 NSE值明显升高 ,血清NSE检测有望成为评估
Objectives:To dectermine whether the concentration of serum neuronspecific enolase(NSE) would be elevated in head trauma patients with diffuse axonal injury(DAI). Mehtods:Thirteen cases of DAI were selected for study according to diagnosis criteria of DAI.CT scans were performed,and blood samples were taken at admission or 12 hours after in jury in all patients.The levels of NSE in the serum were measured. Results:CT scans of 13 patients with DAI showed intracranal hemorrhage in 7 cases,diffuse brain swelling in 3 cases,and negative result in 3 cases,respectively.The mean serm NSE level of the DAI group was elevated significantly compared with the level for normal controls(46.53±24.25 μg/L versus 6.96±2.52 μg/L,P< 0.001 ).The level of NSE were significantly higher in the patients who died or vegetable. Conclusions:Serum NSE was significanlty increased in DAI patients.Measurement of the serum concentration of NSE appears to provide a new valuable parameter of DAI.
出处
《医学研究生学报》
CAS
2000年第3期152-153,,175,,共3页
Journal of Medical Postgraduates
关键词
脑损伤
CT扫描
神经元特异性烯醇化酶
Brain injury
Axons
Tomography
X-ray computed
Neuron-specific enolase
