摘要
目的:观察胸腺肽联合狂犬病疫苗接种对机体γ-干扰素、白细胞介素-2和中和抗体产生的影响。方法:Ⅱ级以下狂犬病暴露人群100例随机分为两组:疫苗组50例,单用狂犬疫苗2.5 U,常规免疫程序接种;胸腺肽组50例,给予50 mg单剂量肌肉注射+狂犬疫苗2.5 U,常规免疫程序接种。在注射前(D0)、注射7 d(D7)、注射6个月(M6)、注射12个月(M12)测定外周血淋巴细胞总数及γ-干扰素、白细胞介素-2水平,注射7 d、注射6个月、注射12个月测定中和抗体水平。结果:外周血淋巴细胞总数两组间无差异;胸腺肽组在注射后7 d白细胞介素-2水平和γ-干扰素水平均高于疫苗组(P<0.05);胸腺肽组在注射后7 d中和抗体产生量高于疫苗组(P<0.05)。结论:加用胸腺肽组注射后7 d中和抗体水平高于单用疫苗组,但6个月和12个月的抗体含量没有差异;两组接种后体内白细胞介素-2和γ-干扰素水平皆增高,白细胞介素-2增加的程度和抗体的产生量呈正相关。
Objective： To observe the effect of γ-interferon,interleukin-2 and neutralizing antibody levels in patients with rabies vaccination combination with thymosin.Methods： 100 patients were divided in to two groups.The vaccine group,50 cases of rabies postexposure patients were given vaccine 2.5 U,routine immunization procedures;the thymosin group,50 cases were given a single dose of thymosin 50 mg each with rabies vaccine 2.5 U together.Blood serums were maintained before injection（D0）,on the 7 days（D7）,on 6 month（M6） and 12 month（M12）.γ-interferon,interleukin-2 and neutralizing antibody and lymphocyte count were detected together.Results： No lymphocyte counts differences was found in two groups.Leukocyte interleukin-2 and interferon-γ levels in thymosin group at 7 days after injection were higher than those in the vaccine group（P〈0.05）.Neutralizing antibody level was significantly higher in thymosin group than in vaccine groups on D7.Conclusion： The levels and positive rate of neutralizing antibodies in thymosin group are higher than those in vaccine group on D7,but there is no difference on M6 and M12.Interleukin-2 and γ-interferon levels are increased after inoculation vaccine,the level of interleukin-2 increased and the amount of antibody production is positively correlated.
出处
《东南大学学报（医学版）》
CAS
2012年第5期550-554,共5页
Journal of Southeast University(Medical Science Edition)
基金
南京市卫生局课题(ykk08121)
