摘要
目的:研究非酒精性脂肪肝(non-alcoholic fatty liver,NAFL)患者血尿酸水平及其与胰岛素抵抗程度的相关性.方法:选取单纯NAFL患者40例,NAFL合并2型糖尿病患者(type2diabetes mellitus,T2DM)72例,健康体检者62名为研究对象.测定体重指数(body mass index,BMI),检测空腹血糖(fasting blood glucose,FBG)、尿酸(serum uric acid,SUA)、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、胆固醇(cholesterol,TC)、甘油三酯(triglyceride,TG)、糖化血红蛋白(glycated hemoglobin,HbA1C)、尿微量白蛋白/尿肌酐(Ualb/UCr)等生化指标并行肝脏B超检查.放射免疫法测定空腹胰岛素(fasting insulin,FINS),计算胰岛素抵抗指数(HOMA IR).结果:NAFL合并T2DM组BMI、SUA、ALT、AST、TG、FBG、FINS、HOMA IR、HbA1C、Ualb/UCr、SF均高于对照组;与单纯NAFL比较,NAFL合并T2DM组胰岛素抵抗及SUA水平更重;相关性研究表明FBG、HOMA IR、HbA1C与SUA呈正相关.结论:NAFL患者存在明显的胰岛素抵抗及高血尿酸血症,且两者具有一定的相关性.降低胰岛素抵抗联合纠正尿酸代谢紊乱对防止NAFL的发生发展具有重要的临床意义.
AIM： To investigate the relationship between se- rum uric acid and insulin resistance in patients with nonalcoholic fatty liver disease （NAFLD） alone and those with NAFLD and type 2 diabe- tes mellitus （T2DM）. METHODS： Forty patients with NAFLD alone, 72 NAFLD patients with T2DM, and 62 healthy controls were studied. Abdominal ultrasound was used for fatty liver examination. Insulin levels were determined by radioimmunoassay （RIA）. Insulin resistance indexes were assessed by the homeostasis assessment insulin resistance （HOMA-IR）. Other biochemical variables were measured using routine methods. RESULTS： Compared to healthy controls, the body mass index （BMI）, alanine aminotransferase（ALT）, aspartate aminotransferase （AST）, choles- terol （TC）, fasting blood glucose （FBG）, fasting insulin （FINS）, HOMA IR, glycated hemoglobin （HbA1C）, UAlb/UCr and SUA significantly in- creased in NAFLD patients with T2DM. Compared to patients with NAFLD alone, insulin resistance was more serious in NAFLD patients with T2DM. Correlation analysis showed that FBG, HOMA IR and HbAIC were closely related with SUA. CONCLUSION： Serum uric acid is closely re- lated with insulin resistance in patients with NAFLD. Therefore, reduction of insulin resis- tance and correction of SUA are important for preventing NAFLD.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第25期2410-2413,共4页
World Chinese Journal of Digestology
关键词
非酒精性脂肪肝性肝病
2型糖尿病
尿酸
胰岛素抵抗
Nonalcoholic fatty liver disease
Type 2diabetes mellitus
Serum uric acid
Insulin resistance
