摘要
目的探讨血清降钙素原（PCT）检测对新生儿败血症早期诊断及对治疗的指导意义。方法选取陕西省渭南市第二医院儿科300例日龄2～26天的新生儿，其中100例正常新生儿为正常对照组，100例新生儿患有单纯败血症者为一般感染组，100例存在合并严重并发症的败血症为严重感染组，应用免疫色谱法进行PCT,C反应蛋白监测，对比分析1周后3组新生儿血浆PCT及C反应蛋白的浓度变化。结果与正常新生儿组相比，一般感染组PCT和C反应蛋白明显升高（X^2=6．5117，P〈0．05）；与一般感染组相比，严重感染组PCT和C反应蛋白升高明显（X^2=3．4361，P〈0．05）；治疗1周后，一般感染组患儿恢复情况优于严重感染组，两纽PCT和hsCRP指标比较差异均存在统计学意义（PCT：t=9．1083，P〈0．05；hsCRP：t=7．4728，P〈0．05）。结论对于新生儿败血症的早期诊断，应首选PCT监测方法，其诊断的敏感度、特异度均优于其他检测方式。
Objective To investigate the clinical significance of serum procalcitonin （PCT） detection in early diagnosis and treatment of neonatal septicemia. Methods Altogether 300 neonates aged 2-26d were recruited including 100 casees of normal neonates （control group）, 100 cases with simple sepsis （general infection group） and 100 cases of sepsis with severe complications （severe infection group）. Immune chromatography was used to monitor PCT and C reactive protein （ CRP）, and the concentrations of PCT and CRP in three groups after one week were compared. Results Compared with control group, the concentrations of PCT and CRP elevated significantly （X^2 =6.5117, P 〈 0.05） in general infection group, and those in severe infection group were obviously higher than those in general infection group （X^2 = 3. 4361 ,P 〈 0.05 ）. After one-week treatment, the recovery of general infection group was superior to that of severe infection group, and the differences in PCT and hsCRP between two groups were significant （PCT： t = 9. 1083, P 〈 0.05;hsCRP： t = 7. 4728 ,P 〈 0.05 ）. Conclusion PCT monitoring method should be the first choice for early diagnosis of neonatal sepsis, and its sensitivity and specificity are superior to those of other methods.
出处
《中国妇幼健康研究》
2012年第5期663-664,共2页
Chinese Journal of Woman and Child Health Research
关键词
降钙素原
新生儿
败血症
诊断
治疗
procalcitonin （PCT）
neonate
sepsis
diagnosis
treatment
