期刊文献+

亚砷酸联合维甲酸、中剂量阿糖胞苷治疗急性早幼粒细胞白血病的临床研究

下载PDF
导出
摘要 目的观察亚砷酸(ATO)、维甲酸(ATRA)联合中剂量阿糖胞苷(ID-Ara-c)治疗急性早幼粒细胞白血病(APL)疗效。方法 36例初治APL患者联合应用ATO、ATRA诱导分化,序贯应用ATO、ATRA及ID-Ara-c方案巩固维持治疗,定期检测PML/RARα融合基因。结果治疗组CR率为94.4%,1年生存率(OS)91.67%,3年OS为86.11%,达到CR的时间短,缓解率高。结论序贯治疗有复发率低,无病生存期长等优点,其不良反应较轻微。
出处 《中外医疗》 2012年第26期118-119,共2页 China & Foreign Medical Treatment
  • 相关文献

参考文献9

  • 1Ohno R,Asou N,Ohnishi K.Treatment of acute promyelocytic leukemia: strategy toward further increase of cure rate[J].Leukemia,2003,17(8): 1454-1463.
  • 2张鹏,王树叶,胡龙虎,邱凤芹,杨惠芬,肖彧君,李晓霞,韩雪英,周晋,刘澎.三氧化二砷治疗急性早幼粒细胞白血病七年总结——附242例分析[J].中华血液学杂志,2000,21(2):67-70. 被引量:320
  • 3Jing Y,Waxman S.The design of selective and non-selective combination therapy for acute promyelocytic leukemia[J].Curr Top Microbiol Immunol,2007,313:245-269.
  • 4Giani M,Koken MHM,Chelbi-Alix MK,et al.Combined arsenic and retinoic acid treatment enhances differentiation and apoptosis in arseni-cresistant NB4 cells[J].Blood,1998,91(11):4300-4310.
  • 5Bandini G, Zuffa E;Rosti G,et al.Long-term outcome of adults with acute myelogenous leukaemia: results of a prospective,randomized study of chemotherapy with a minimal follow-up of 7 years[J].Bri J Haematol, 1991,77:486-490.
  • 6Ades L,Montesinos P,Chevret S,et al.Treatment of newly diagnosed acute promyelocytic leukemia in the elderly:a joint analysis of the French- Belgian-Swiss and PETHEMA groups[J].Blood(ASH annual meeting abstracts),2009,114:Abstract 845.
  • 7Burnett AK,Grimwade D,Solomon E,et al.Presenting white blood cell count and kinetics of molecular remission predict prognosis in acute promyelocytic leukemia treated with all-trans retinoic acid:result of the Randomized MRC Trial[J].Blood,1999,93(12):413141-413143.
  • 8Martin S ,Tallman,Chadi Nabhan, et al. Acute promyelocytic leukemia: evolving therapeutic strategies[J].Blood,2002, 99 (3) : 759-767.
  • 9Haverkamp W,Breithardt G,Camm A J,et al.The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs:clinical and regula-tory implications.Report on a policy conference of the European society of cardiology[J].Eur H Eeart J,2000,21:1216-1231.

二级参考文献3

  • 1贝政平,3200个内科疾病诊断标准,1998年
  • 2张之南,血液病诊断及疗效标准(第2版),1998年
  • 3王世俊,金属中毒(第2版),1988年

共引文献319

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部