摘要
目的运用虚燥更平散治疗围绝经期高血压病,观察治疗前后神经递质相关指标变化,探讨虚燥更平散治疗围绝经期高血压病的机理。方法选取66例围绝经期高血压病阴虚内燥证患者随机分成治疗组30例和对照组36例,检测治疗前后血压、神经肽Y(NPY)、神经降压素(NT)、去甲肾上腺素(NE)水平,并做统计分析比较。结果治疗组与对照组比较NPY、NE水平较治疗前降低(P<0.05),NT无统计学意义(P>0.05);2级高血压治疗组与对照组比较血浆NPY、NE水平较治疗前降低(P<0.05)。结论运用虚燥更平散治疗后能降低围绝经期高血压病阴虚内燥证患者血浆NPY、NE水平,提示虚燥更平散对围绝经期高血压病阴虚内燥证患者神经递质水平具有调节作用。
Objective To observe the changes of neurotransmitter-related indexes before and after the treatment of climacteric hypertension with Xuzao Gengping San and study the mechanism. Methods The patients （ n = 66） with climacteric hypertension （ syndrome of yin deficiency and internal dryness） were randomly divided into treatment group （ n = 30 ） and control group （ n = 36 ）. The changes of blood pressue, neusopeptide Y （NPY）, neurotensin （NT） and noradrenalin （NE） were detected, analyzed and compared. Results The levels of NPY and NE decreased in treatment group and control group （P 〈 0.05 ） than before the treatment and the change of NT level had no statistical significance （ P 〉 0.05 ）. The levels of NPY and NE decreased in treatment group compared with control group （ P 〈 0.05 ）. Conclusion Xuzao Gengping San used for treating climacteric hypertension has decreased the levels of plasma NPY and NE, which indicates that Xuzao Gengping San has a regulative effect on the neurotransmitters relating to climacteric hypertension.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2012年第9期634-637,共4页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家自然科学基金项目(No.30960478)
新疆自治区科技支撑项目(No.201133123)
