摘要
目的观察黄柴川杏汤对慢性阻塞性肺疾病(COPD)模型大鼠的保护作用。方法采用烟熏加气管内注入脂多糖法复制COPD大鼠模型,分组观察黄柴川杏汤对COPD模型大鼠的体重、温水游泳时间、呼吸频率及肺功能各指标的影响。结果黄柴川杏汤可提高COPD模型大鼠体重增幅,减慢其呼吸频率,延长其温水游泳时间。结论黄柴川杏汤可有效改善COPD模型大鼠多项肺功能指标,改善其营养状态,提高其活动能力,对COPD模型大鼠有一定的保护作用。
OBJECTIVE To observe the protective effect of Huangchai Chuanxing decoction in chronic obstructive pulmonary disease（COPD）model of rats.METHODS COPD rats were obtained by smoking and intratrachem injection of lipopolysaccharide.The effect of Huangchai Chuanxing decoction on COPD rat models of weight,warm water swimming time,breathing frequency and lung function index.RESULTS Huangchai Chuanxing decoction could improve COPD model rats by weight,slow its breathing and extend its warm water swimming time.CONCLUSION Huangchai Chuanxing decoction can effectively improve the COPD rat models of multiple pulmonary function index,the nutrition,its activity ability,and play a protective role in rat models of COPD.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2012年第5期523-525,共3页
West China Journal of Pharmaceutical Sciences
关键词
黄柴川杏汤
慢性阻塞性肺疾病
动物模型
肺功能
Huangchai Chuanxing decoction
Chronic obstructive pulmonary disease
Animal model
Lung function
