摘要
目的了解戊型肝炎患者重叠慢性乙型肝炎病毒感染后的临床表现、肝功能变化及预后。方法收集急性戊型肝炎患者65例和急性戊型肝炎重叠慢性乙型肝炎感染48例,对两组患者进行临床分析,应用酶联免疫吸附试验检测两组患者HBV标志物及抗HEV IgM。结果总胆红素、凝血酶原活动度、白蛋白、重型肝炎发病率及病死率在重叠感染组和单纯急性戊型肝炎组之间比较,差异有显著性。结论戊型肝炎重叠慢性乙型肝炎病毒感染患者肝功能损害严重,病死率高,预后差。
[Objective] To compare the influence of hepatitis B virus （HBV） infection on clinical features of hepatitis E virus （HEV）, the degree of hepatic function impairments and prognosis of hepatitis E patients with chronic hepatitis B superinfection. [ Methods ] 65 hepatitis E patients and 48 hepatitis E patients with chronic hepatitis B superinfection were studied and compared. HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc and anti-HEV IgM were detected respectively by enzyme linked immunosorbent assay. [ Results ] There were significant differences of total bilirubin（TBIL）, albumin（ALB）, and prothrombin activity（PTA） between hepatitis E patients superinfected with HBV and hepatitis E patients 0. The former group had a poorer prognosis with a 29.17% occurrence rate of severe hepati- tis and a 10.42% death rate while in the latter group the corresponding rate were just 12.31% and 1.54%. [Conclusion ] Re-infection with chronic HBV, in those HEV patients, severely damaged their hepatic functions and increased their mortality.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2012年第24期76-78,共3页
China Journal of Modern Medicine
