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组织芯片法检测胃癌组织中HIF-1α和DEC1的表达及其意义

Expressions and clinical significances of HIF-1α and DEC1 in tissues array of gastric carcinoma
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摘要 目的研究胃癌组织中HIF-1α和DEC1的表达情况及其意义。方法应用组织芯片方法检测162例胃癌组织和32例癌旁组织中HIF-1α和DEC1蛋白的表达。结果 HIF-1α在胃癌组织和癌旁组织中表达的阳性率分别为37.04%(60/162)和9.38%(3/32),两者差异有统计学意义(P<0.05);HIF-1α的表达与肿瘤分期、浸润深度和淋巴结转移有关(P<0.05)。DEC1在胃癌组织及癌旁组织中表达的阳性率分别为11.11%和3.13%,两者之间差异无统计学意义(P>0.05)。结论 HIF-1α在胃癌组织中高表达,与胃癌的发生、发展及转移密切相关;而DEC1在胃癌组织中低表达,其临床价值尚有待于进一步研究。 【Objective】 To investigate the expressions of HIF-1α and DEC1 in gastric carcinoma.【Methods】 The TMA technology was used to detect the expression of HIF-1α and DEC1 in 162 gastric carcinoma（GC） and 32 para-carcinoma.【Results】 The positive expression rates of HIF-1α in gastric carcinoma and in paired para-carcinoma were 37.04%（60/162）,9.38%（3/32） respectively（P 0.05）.The expression of HIF-1α was significantly associated with TNM stage,the depth of invasion and lymph node metastasis（P 0.05）.The positive expression rates of DEC1 in gastric carcinoma and in paired para-carcinoma were 11.11%（18/162）,3.13%（1/32） respectively（P 0.05）.【Conclusions】 HIF-1α was over-expressed in gastric carcinoma,and was correlated with the oncogenesis,development and metastasis of gastric carcinoma.The expression of DEC1 in gastric carcinoma was lower,and its clinical vanue needs to be studied further.
作者 朱大刚 单国平 戎亚雄 刘建跃 朱毓平 薛志新
机构地区 江苏大学附属武进医院普外科
出处 《中国现代医学杂志》 CAS CSCD 北大核心 2012年第23期72-75,共4页 China Journal of Modern Medicine
关键词 组织芯片 免疫组织化学 胃癌 HIF-1Α DEC1 tissue microarrays immunohistochemistry gastric cancer Hypoxia-inducible factor 1 Alpha differentiated embryo-chondrocyte expressed gene 1
分类号 R735.2 [医药卫生—肿瘤]
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参考文献14

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二级参考文献12

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中国现代医学杂志
2012年 第23期

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