摘要
目的评价艾司西酞普兰治疗老年抑郁症疗效及安全性。方法 64例老年抑郁症患者随机分为艾司西酞普兰组与舍曲林组,疗程6周。采用汉密尔顿抑郁量表(HAMD)评定临床疗效,不良反应量表(TESS)评定不良反应。结果艾司西酞普兰组显效率为78.1%,舍曲林组75%,两组比较差异无显著性(χ2=0.22,P>0.05);艾司西酞普兰组治疗第2周末与舍曲林组HAMD评分比较有显著性差异(t=3.66,P<0.05);艾司西酞普兰组不良反应发生率40.6%,舍曲林组43.8%,两组比较差异无显著性(χ2=0.06,P>0.05)。结论艾司西酞普兰与舍曲林治疗老年抑郁症疗效相当,艾司西酞普兰起效较舍曲林快。
Objective To explore the efficacy and safety of escitalopram and sertraline in the treatment of senile patients with depression.Methods A total of 64 senile patients with depression were randomly assigned into escitalopram group and sertraline group for 6 weeks.Clinical effectiveness were evaluated by HAMD,and adverse reactions were assessed with TESS.Results The response rate was 78.1% in escitalopram group and 75% in sertraline group,and there was no significant difference between two groups（χ2=0.22,P0.05）.At the end of 2 week treatment,there was significant difference in the scores of HAMD between two groups（t=3.66,P0.05）.The adverse reactions were 40.6% in escitalopram group and 43.8% in sertraline group,and there was no significant difference between two group（χ2=0.06,P0.05）.Conclusions The efficacy of escitalopram in treating senile depression is similar to those of sertraline.Escitalopram takes effect more quickly than sertraline.
出处
《中国健康心理学杂志》
2012年第9期1296-1297,共2页
China Journal of Health Psychology
